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Prof Adele Fielding
418
UCL Cancer Institute
72 Huntley St
London
WC1E 6DD
Tel: 0207 830 2833
Fax: 0207 830 2092
Appointment
  • Professor of Haematology
  • Research Department of Haematology
  • Cancer Institute
  • Faculty of Medical Sciences
Biography

My undergraduate education was at UCL. Thereafter, I completed my postgraduate medical training in general medicine and haematology in various London hospitals. I undertook my PhD in the MRC Centre for Protein Engineering, part of the MRC LMB in Cambridge with Stephen Russell as my supervisor, working on targeting entry of retroviral vectors to haemaopoietic stem cells. Upon realising there was more mileage in using replicating viruses for  cancer therapy, I switched to working with measles virus and subsequently started my own lab at Mayo Clinic College of Medicine Rochester MN USA where I was appointed as Assistant Professor of Medicine between 1999 and 2003. I returned to UCL in 2003 with initial salary support from Leukaemia and Lymphoma Research UK. I am a Professor in Haematology at UCL. As an Honorary Consultant in Haematology at UCLH NHS Trust I see patients with acute leukaemia and run a busy trials programme. I attend on the bone marrow transplant inpatient service. I am presently Director of R and D for the Royal Free London Foundation NHS Trust.

Research Groups
Research Themes
Research Summary

My foremost goal is to improve the outcome for adults with acute lymphoblastic leukaemia. As a clinician scientist,  I chair the UK National Cancer Research Institute Adult ALL subgroup which is responsible for the UKs clinical trials programme for ALL. I am Chief Investigator of UKALL14 and UKALL60+, the UK's frontline academically-initiated trials for ALL. My research lab program takes advantage of the opportunity to do translational work arising from these trials - we have a range of projects which examine basic aspects of ALL biology in various models

Our research lab program takes advantage of the opportunity to do translational work arising from these trials - we have a range of projects which examine basic aspects of ALL biology in various models. We collaborate closely with the group of Anthony Moorman in Newcastle and with Elli Papaemanuil and Peter Campbell from the Sanger Centre.

Another goal in the lab is the development of attenuated oncolytic measles virus as a therapy for ALL. We are specifically interested in the mechanistic aspects of how measles virus kills cancer cells leaving non-transformed cells relatively unharmed. We are also investigating on how measles virus interacts with the immune system during cancer treatment. Both of these projects touch on basic measles virology. Our projects are currently funded by Leukaemia and Lymphoma Research and CR UK.

We also run the UK's Adult ALL minimal residual disease service; we carry out patient-specific immunoglobulin heavy chain and T cell receptor quantification according to the standards established by the EuroMRD group and participate fully in EuroMRD

Selected research projects

  • Personalising Therapy for Adults with ALL - a CRUK program grant. 
  • Combining CD20 targeted, oncolytic measles virus with rituximab and corticosteroids in the treatment of acute lymphoblastic leukaemia.
  • The Role Of Mesenchymal Stromal Cells In The Onset, Progression And Treatment Resistance Of Adult Acute Lymphoblastic Leukaemia.
  • IKZF1 deletions in adult ALL; the chicken or the egg?
  • Characterizing the mechanisms underlying measles virus mediated oncolysis in a stromal model of cellular transformation.

 Our projects are funded by Leukaemia and Lymphoma Research and CR UK.

Teaching Summary

I teach undergraduate medical students. I teach on the cancer MSc course and take MSc students into the lab. I supervise several PhD students.

Appointments
01-AUG-2011 Director of Research and Development   Royal Free London NHS Trust, United Kingdom
Academic Background
2003 ECFMG Certification Educational Commission for Foreign Medical Graduates – Medicine Educational Commission for Foreign Medical Graduates
1999 PhD Doctor of Philosophy University of London
1998 MRCPath Member of the Royal College of Pathologists – Haematology Royal College of Pathologists, UK
1991 MRCP Member of the Royal College of Physicians – Medicine Royal College of Physicians
1988 MBBS Bachelor of Medicine/Bachelor of Surgery – Medicine University College London
1985 BSc Hons Bachelor of Science (Honours) – Psychology University of London
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