Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Prof Adele Fielding
UCL Cancer Institute
72 Huntley St
Tel: 0207 830 2833
Fax: 0207 830 2092
Prof Adele Fielding profile picture
  • Honorary Clinical Professor
  • Research Department of Haematology
  • Cancer Institute
  • Faculty of Medical Sciences

My undergraduate education was at UCL. Thereafter, I completed my postgraduate medical training in general medicine and haematology in various London hospitals. I undertook my PhD in the MRC Centre for Protein Engineering, part of the MRC LMB in Cambridge with Stephen Russell as my supervisor, working on targeting entry of retroviral vectors to haemaopoietic stem cells. Upon realising there was more mileage in using replicating viruses for  cancer therapy, I switched to working with measles virus and subsequently started my own lab at Mayo Clinic College of Medicine Rochester MN USA where I was appointed as Assistant Professor of Medicine between 1999 and 2003. I returned to UCL in 2003 with initial salary support from Leukaemia and Lymphoma Research UK. I am a Professor in Haematology at UCL. As an Honorary Consultant in Haematology at UCLH NHS Trust I see patients with acute leukaemia and run a busy trials programme. I attend on the bone marrow transplant inpatient service. I was Director of R and D for the Royal Free London Foundation NHS Trust for several years until January 2018.

Research Groups
Research Themes
Research Summary

My foremost goal is to improve the outcome for adults with acute lymphoblastic leukaemia. As a clinician scientist,  I chair the UK National Cancer Research Institute Adult ALL subgroup which is responsible for the UKs clinical trials programme for ALL. I am Chief Investigator of UKALL14 and UKALL60+, the UK's frontline academically-initiated trials for ALL. My research lab program takes advantage of the opportunity to do translational work arising from these trials - we have a range of projects which examine basic aspects of ALL biology in various models

Our research lab program takes advantage of the opportunity to do translational work arising from these trials - we have a range of projects which examine basic aspects of ALL biology in various models. We collaborate closely with the group of Anthony Moorman in Newcastle and with Elli Papaemanuil and Peter Campbell from the Sanger Centre.

Another goal in the lab is the development of attenuated oncolytic measles virus as a therapy for ALL. We are specifically interested in the mechanistic aspects of how measles virus kills cancer cells leaving non-transformed cells relatively unharmed. We are also investigating on how measles virus interacts with the immune system during cancer treatment. Both of these projects touch on basic measles virology. Our projects are currently funded by Leukaemia and Lymphoma Research and CR UK.

We also run the UK's Adult ALL minimal residual disease service; we carry out patient-specific immunoglobulin heavy chain and T cell receptor quantification according to the standards established by the EuroMRD group and participate fully in EuroMRD

Selected research projects

  • Personalising Therapy for Adults with ALL - a CRUK program grant. 
  • Combining CD20 targeted, oncolytic measles virus with rituximab and corticosteroids in the treatment of acute lymphoblastic leukaemia.
  • The Role Of Mesenchymal Stromal Cells In The Onset, Progression And Treatment Resistance Of Adult Acute Lymphoblastic Leukaemia.
  • IKZF1 deletions in adult ALL; the chicken or the egg?
  • Characterizing the mechanisms underlying measles virus mediated oncolysis in a stromal model of cellular transformation.

 Our projects are funded by Leukaemia and Lymphoma Research and CR UK.

Teaching Summary

I teach undergraduate medical students. I teach on the cancer MSc course, the Infection and Immunity BSC course and routinely host MSc students in the lab. I supervise several PhD students.

01-AUG-2011 Director of Research and Development   Royal Free London NHS Trust, United Kingdom
Academic Background
2003   Certification Educational Commission for Foreign Medical Graduates Educational Commission for Foreign Medical Graduates
1999   Doctor of Philosophy University of London
1998   Member of the Royal College of Pathologists Royal College of Pathologists, UK
1991   Member of the Royal College of Physicians Royal College of Physicians
1988   Bachelor of Medicine/Bachelor of Surgery University College London
1985   Bachelor of Science (Honours) University of London
Some IRIS profile information is sourced from HR data as explained in our FAQ. Please report any queries concerning HR data shown on this page to hr-services@ucl.ac.uk.
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by