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Prof Andrea Malaspina
Prof Andrea Malaspina profile picture
  • Professor of Clinical Neurology
  • Department of Neuromuscular Diseases
  • UCL Queen Square Institute of Neurology
  • Faculty of Brain Sciences

Professor Andrea Malaspina has extensive clinical expertise in neuromuscular disorders and a track-record of research in biological mechanisms and biomarkers of neurodegeneration. He completed his specialist training in Neurology and a PhD in Molecular Neurobiology at Imperial College London in 2021. He has been a Consultant Neurologist at Barts Health since 2002, with an active role in Clinical Neurology and research interests in neuromuscular and neurodegenerative disorders. In 2009, he has founded the Royal London (now Barts Health) MND Care and Research Centre. He has been the MND Research Director for DeNDRoN and for the LCRN North-Thames. In 2012, he took up a formal academic appointment as Clinical Senior Lecturer with the Barts and The London Medical School and in 2015 he became Reader in Clinical Neurology. In 2019, as Professor of Neurology, he established the neurodegeneration group at the Blizard Institute. He has been recently appointed Clinical and Academic Lead of the newly created ALS Centre at the National Hospital for Neurology and Neurosurgery (Queen Square Motor Neuron Disease Centre). His focus on patient’s care and research has supported a portfolio of research projects, teaching modules, nation-wide and international biobanking projects and public engagement activities.

Research Summary

My research and clinical interests encompass neurodegenerative and neuroinflammatory pathologies bridging brain and the neuromuscular systems, with motor neurone disease as the main focus of research. I have established a multi-disciplinary experimental approach for the identification and clinical validation in bliofluids of molecular signals linked to disease initiation and progression. This work has generated potential biomarkers and therapeutic targets for neurodegenerative disorders. Central to this research endeavour in both patients and animal models is the search for molecular mechanism underpinning clinical heterogeneity and the role of ageing. Building on a wealth of clinical and biological data, our aim is to develop a systemic model of disease progression by tracking the expression in biofluids of molecules linked to the immune response, metabolism and also to senescence. Work on biomarkers includes the detection of naturally occurring auto-antibodies to brain proteins, of mediators linked to initiation and resolution of inflammation and of neurofilaments as well as circulating protein aggregates which mirror brain pathology. 

Teaching Summary


MSc in “Translational Neuroscience”: Co-Lead and in charge of the “Neurodegeneration” study   module. 

BSc in Neuroscience and Mental Health, Imperial College London: Lecturer: “Biomarkers for the clinical stratification of neurodegenerative disorders”. 


04-JAN-2021 Professor of Neurology Neuromuscular Department, MND Centre Queen Square Institute of Neurology, United Kingdom
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