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Dr Audrey Mercer
UCL School of Pharmacy Department of Pharmacology
29-39 Brunswick Square
London
WC1N 1AX
Tel: 0207 753 5890
Appointment
  • Lecturer
  • Pharmacology
  • UCL School of Pharmacy
  • Faculty of Life Sciences
Biography

Following a DEA (french predoctoral qualification) at the University of Montpellier, Dr Mercer moved to the department of Physiology, Royal Free Hospital Medical School, where she started a PhD under the supervision of Professor Alex Thomson. In 2003, she moved to the School of Pharmacy and was awarded her PhD in 2005. Dr Mercer became a RCUK Academic Fellow at the School in 2007 and was appointed as a lecturer in 2012.

Research Themes
Research Summary

Investigation of CA2 hippocampal circuitry. The project focusses on a region of the hippocampus, the CA2 region, that is uniquely resistant to damage in temporal lobe epilepsy, but which demonstrates abnormalities early in the onset of schizophrenia and in bipolar disorder (sometimes known as manic depressive illness). These abnormalities involve inhibitory interneurones that control and coordinate the flow of information and the components of an experience that we recognise as novel and/or relevant to our behaviour and which we then retain. Dual intracellular recordings with pharmacology and biocytin filling are performed to study the morphological and physiological characteristics of these CA2 neurones and their synaptic properties.


Development of a data-driven hippocampal model (Human Brain Project). Our primary goal is to develop and test strategies for fostering community convergence through data-driven reconstruction and simulation of the hippocampus.


Effect of Exendin-4 on hyposmia and piriform cortex in a pre-motor model of Parkinson’s Disease. Since dopamine (DA) loss in the substantia nigra is a prime cause of motor dysfunction in Parkinson’s disease (PD), animal models of PD have traditionally involved acute depletion of brain DA. However, many patients suffer early non-dopaminergic pre-motor symptoms including depression, cognitive impairment and loss of smell (hyposmia), with the latter thought to precede diagnosis by several years. By using a pre-motor model to determine the changes in the olfactory (piriform) cortex that are associated with hyposmia and have convergence with actual ESPD-like pathology, we have shown that exendin-4 is able to prevent these changes within a short time window, representing an important step forward towards recognising new early-stage therapies for PD patients.

Teaching Summary

Undergraduate teaching in MPharm programme


Year 2 Leader
Year 2 PHAY 0007 Body Systems Therapeutics 2 module leader
Academic member of UCL School of Pharmacy Student Experience Group

  • Year 2 teaching includes 
PHAY0008 pain lectures and integrated workshops
PHAY0008 workshops on schizophrenia and Parkinson’s Disease 
PHAY0007 Cardiovascular workshops
PHAY0007 Endocrinology lectures and workshops 
Coordination and teaching of Year 2 Integrated Therapeutics Workshops

  • Year 3 teaching on the Aging brain option: lecture and marking of poster presentations. 

  • Supervision of Year 4 MPharm research projects

Postgraduate teaching 

  • MSc Experimental pharmacology- journal clubs, poster presentations, meta-analysis projects 
  • MSc Drug Discovery- New drug target in CNS
  • Supervision of MSc students 

Appointments
01-OCT-2012 Lecturer Pharmacology UCL School of Pharmacy, United Kingdom
Academic Background
2012 PGCLTHE Postgraduate Certificate in Learning and Teaching in Higher Education – Teaching London School of Hygiene and Tropical Medicine
2005 PhD Doctor of Philosophy – Neuroscience University of London
2000 MA Diplôme d'études approfondies – Endocrinology Universite de Rennes I
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