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- Professor Wellcome Chair of Pharmacology
- Pharmaceutical & Biological Chemistry
- UCL School of Pharmacy
- Faculty of Life Sciences
Following a BSc in Physiology at Bedford College, University of London (1975), Alex moved to the Physiology Department in Bristol to study for her PhD with Dr Tony Ridge. After two postdoctoral years in the Anatomy Department in Bristol, she moved to the University Laboratory of Physiology in Oxford in 1980 with a Beit Memorial Fellowship, joining Somerville College as a Fulford Junior Research Fellow in 1982.
In 1985 Alex moved to the Physiology Department, University College Cardiff, as a Wellcome Lecturer. Here the paired intracellular recordings from synaptically connected cortical neurones that have become the hallmark of the lab began. She moved to the Department of Physiology, Royal Free Hospital Medical School, in 1988, again as a Wellcome Lecturer, becoming Professor of Neurophysiology at the newly combined Royal Free and University College Medical School in 1998. In 2002, Professor Thomson moved to The School of Pharmacy where she was Head of the Pharmacology Department until 2007.
We continue to study the synaptic circuitry
of neocortex and hippocampus and the pre- and post-synaptic
determination and localization of function. Dual/triple intracellular
recordings with pharmacology and biocytin-labelling of connected
neurones in brain slices detail the properties of
synaptic connections and investigate underlying mechanisms. Morphological analyses investigate the specificity with which
cells of a particular class in a given layer select target other neurones.
Current Projects :
2008-2013 Mechanisms underlying synapse-specific clustering of GABAA receptors Funded by MRC. Co-PIs Dr J. Jovanovic, Dr A Mercer and Pr FA Stephenson
On each side of a synapse, proteins cluster into highly specific, complex functional units. Synaptic proteins are highly specialised components. We know something of their structures, their interactions with each other and that subtly different components are used by different types of synapse. What we do not yet understand is how they are selected and inserted at just the right place, or how each combination of components leads to one set of distinctive functional properties. A first requirement is for two neurones, one on either side of the synapse, is to recognise each other, but how does it do it? Sheer complexity has, until recently, precluded a deeper understanding. The tools needed to probe further are however, becoming available and with them, new insight into the mechanisms that underlie this precision.
2011-2014 Selective targeting of synapses to specific dendritic locations and their modulation by voltage-gated channels. Funded by the MRC. Co-PIs Dr A Ruiz and Dr M Shah
Evidence for specificity in the properties of synaptic connections is growing, though we know less about the smaller dendritic branches of pyramidal cells and how the properties of postsynaptic dendritic compartments shape individual synaptic inputs and their summation with events from neighbouring synapses. Many different mechanisms contribute to dendritic properties; mechanisms that may be differentially expressed in different pyramidal cells, different dendrites and dendritic compartments. We will test the hypothesis that each class of synaptic input to a given class of postsynaptic cell is distributed over a highly specific region of dendritic space that is homogeneous in its active and passive properties, involves only certain types of dendrites and is at a given electrotonic distance from the soma.
International Collaboration :
The Human Brain Project European Commission FET Flagship Programme. Led by Prof Henry Markram and co-directors Prof's Richard Frackowiak and Karlehinz Meier and federating more than 80 European and international research institutions.
The goal of the Human Brain Project is to pull together all our existing knowledge about the human brain and to reconstruct the brain, piece by piece, in supercomputer-based models and simulations. The models offer the prospect of a new understanding of the human brain and its diseases and of completely new computing and robotic technologies. On January 28, the European Commission supported this vision, announcing that it has selected the HBP as one of two projects to be funded through the new FET Flagship Program.
37 years of teaching medical, dental, veterinary, science and pharmacy students.
|01-JAN-2012||Wellcome Professor of Pharmacology||Pharmacology||UCL School of Pharmacy, United Kingdom|
|01-SEP-2002||Wellcome Professor of Pharmacology||Pharmacology||The School of Pharmacy, Univ London, United Kingdom|
|1998 – 2002||Prof Neurophysiology||Physiology||Royal Free and UCL Medical School, United Kingdom|
|1988 – 1998||Wellcome Lecturer/Senior Lecturer/Reader||Physiology||Royal Free Hospital School of Medicine, United Kingdom|
|1985 – 1988||Wellcome Lecturer||Physiology||University College Cardiff, United Kingdom|
|1980 – 1985||Independent Research Fellow/Beit Memorial Fellow||Univ. Lab Physiology||Oxford University, United Kingdom|
|1978 – 1980||Postdoc||Anatomy||Bristol University, United Kingdom|
|1975 – 1978||PhD Student||Physiology||Bristol University, United Kingdom|