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Dr Andrei Okorokov
2.3.03A
Wolfson Institute for Biomedical Research
Gower Street
London
WC1E 6BT
Appointment
  • Lecturer
  • Wolfson Inst for Biomedical Research
  • Div of Medicine
  • Faculty of Medical Sciences
Biography

2004-date Lecturer, UCL, WIBR, London

2002-2004 Senior Research Fellow, Birkbeck College, London

1995-2002 Postdoc, University of York

1991-1994
Researcher, Engelhardt Institute of Molecular Biology, Moscow

1987-1991 PhD, Moscow All-Union Institute of Genetics, Russia
Research Themes
Research Summary

Chromosome Stability Group

Our group’s research programme brings together cell, molecular and structural biology of the protein machineries and signalling pathways controlling and maintaining the integrity of our chromosomes. We have three main areas of research interest:


p53 tumour suppressor

We are exploring how cellular tumour suppressors coordinate DNA metabolism processes. Our research focuses on the p53 protein, a major tumour suppressor activated in response to DNA damage. This protein can induce either cell growth arrest and DNA repair, or cell death. Our recently solved structures of the complete p53 tetramer and p53 in complex with its specific DNA target outlay structure-function relationship principles for this paramount “Guardian of Genome”.  

SIRT1 and chromosomal maintenance

Human SIRT1 is a NAD+-dependent protein deacetylase that belongs to the conserved Sirtuin family. It participates in cellular controls of gene expression, metabolism, genomic stability and anti-ageing. Our recent work demonstrated that human SIRT1 is also an essential contributor to chromosomal condensation during mitosis. Lack of SIRT1 in human cells leads to improper chromosome condensation, chromosome "bridges" and breakage, and aneuploidy, indicating that SIRT1 activity in mitosis is vital for chromosome stability. 

DNA replication

The first line of the cells’ defence lies at the very beginning of the DNA replication process. Part of our research is focused on the assembly and function of the human DNA replication protein machinery, in particular the process of DNA replication initiation. We are currently working on the human DNA replication initiation protein Mcm10,and are trying to elucidate its structure-function relationship using amultidisciplinary approach. 

Academic Background
1991 PhD Doctor of Philosophy – Genetics Russian Academy of Sciences
1987 MSc Master of Science – Biochemistry  
04-06 CLTHE_1 Certificate in Learning and Teaching in HE Part 1 – Academic studies in Higher Education University College London
04-06 CLTHE_2 Certificate in Learning and Teaching in HE Part 2 – Academic studies in Higher Education University College London
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