1. Ageing and health - I am director of the English Longitudinal Study of Ageing (ELSA), a large population-based study of a representative sample of men and women aged 50 and over living in England http://www.ifs.org.uk/elsa/. The study forms the basis of a range of research involving economics, psychosocial factors, health, cognition, biology and genetics. 2. The studies that I and my colleagues and students have carried out using ELSA and other population cohorts include work on dementia, frailty, subjective wellbeing and health, and social factors such as social isolation and loneliness in relation to health, cognition and wellbeing. We have also completed studies of discrimination on the basis of age and body weight, subjective perceptions of age, health literacy and other issues. 3. Psychobiology of health and disease - The purpose of this programme is to understand the biological processes through which social status and other psychosocial factors influence disease risk. It involves laboratory studies of the influence of psychosocial factors on cardiovascular, neuroendocrine and immune function, naturalistic studies of blood pressure, cortisol and other measures during everyday life, and clinical studies of patients with coronary heart disease. We have been particularly interested in the impact of mental stress on inflammatory, metabolic, and haemostatic processes; the links between physiological responses and psychosocial risk factors such as low socioeconomic position, depression, work stress, optimism and loneliness; the prospective associations between acute physiological responses to emotional stress and the development of cardiometabolic disease; the complex interplay between psychological processes, neuroendocrine activation, inflammation, depression, and recovery following acute cardiac events such as myocardial infarction; the impact of stress-related biology on biological ageing; and the use of novel biomarkers in social epidemiology. 4. Health behaviour research - Behaviours such as dietary choice, smoking and physical exercise are important determinants of health and disease risk. We carry out studies of the determinants of health behaviours, and work on the use of behavioural counselling to modify risk behaviours.