My research focuses on the causes, progression and complications of  chronic kidney disease (CKD) with an emphasis on endemic nephropathies of unknown cause (CKDu). I am principal investigator of an ongoing cohort study investigating the causes of the epidemic of CKDu in Nicaragua. I co-chair the international DEGREE initiative and act as a co-investigator/international advisor on a number of studies globally, including work being conducted in Peru, Malawi, India, and Sri Lanka. 

In the UK I am a co-principal investigator of HEROIC, an observational study of patients with diabetic kidney disease in North and East Central London and I helped lead the analytical team undertaking the National CKD Audit for England and Wales. 

Alongside population health, my group uses a wide variety of molecular biological, in vivo, and clinical research techniques and aims to leverage novel technologies to gain insight into CKD and CKD-associated complications.