UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Miss Bryony McCord
321
Rayne Building
London
WC1E 6JF
Miss Bryony McCord profile picture
Appointment
  • Student
  • Div of Medicine
  • Faculty of Medical Sciences
Research Summary

Bry McCord is a PhD student supervised by Professor Richard Day within the Applied Biomedical Engineering Group (ABEG), Centre for Precision Healthcare. Her project focusses on the interplay between inflammatory mediators and degenerative features of sporadic inclusion body myositis (sIBM) in vitro. Specifically, the research focuses on the role of three inflammatory factors on aberrant sarcoplasmic TDP-43 and p62 aggregations. These factors are:

(1) IL-1β and IFNγ 

(2) Macrophages

(3) CD8+ T-cells 


Further, she is interested in the effect of these inflammatory factors on the ability of cultured skeletal muscle myotubes to generate contractile force. By utilising advanced 3D myobundle culture techniques, it is possible to study the effect of these inflammatory factors on tetanic force production. This allows for the investigation of clinically-relevant effects, as the primary symptom of sIBM is muscle weakness.

Some IRIS profile information is sourced from HR data as explained in our FAQ. Please report any queries concerning HR data shown on this page to hr-services@ucl.ac.uk.
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by