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Ms Bryony McCord
Rayne Building
Ms Bryony McCord profile picture
  • Research Assistant
  • Developmental Biology & Cancer Dept
  • UCL GOS Institute of Child Health
  • Faculty of Pop Health Sciences
Research Summary

Bry McCord is a PhD student supervised by Professor Richard Day within the Applied Biomedical Engineering Group (ABEG), Centre for Precision Healthcare. Her project focusses on the interplay between inflammatory mediators and degenerative features of sporadic inclusion body myositis (sIBM) in vitro. Specifically, the research focuses on the role of three inflammatory factors on aberrant sarcoplasmic TDP-43 and p62 aggregations. These factors are:

(1) IL-1β and IFNγ 

(2) Macrophages

(3) CD8+ T-cells 

Further, she is interested in the effect of these inflammatory factors on the ability of cultured skeletal muscle myotubes to generate contractile force. By utilising advanced 3D myobundle culture techniques, it is possible to study the effect of these inflammatory factors on tetanic force production. This allows for the investigation of clinically-relevant effects, as the primary symptom of sIBM is muscle weakness.

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