Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Dr Catia Andreassi
Dr Catia Andreassi profile picture
  • Senior Research Associate
  • Lab for Molecular Cell Bio MRC-UCL
  • Faculty of Life Sciences
Research Summary

My research work focuses on understanding the role of mRNA metabolism in brain development and disease. Initially, I studied the patho-physiology of Spinal Muscular Atrophy, a motor neuron disease. In SMA, mutations of SMN, a ubiquitously expressed protein involved in several aspects of RNA metabolism, cause a neuronal-specific phenotype. In 2005 I joined the Riccio lab at UCL where I have been leading a project aimed at investigating the role of Nerve Growth Factor in mRNA localization in axons of developing sympathetic neurons. The project relies on the use of sophisticated cell culture models, such as compartmentalized chambers, and highly specialized molecular biology techniques, such as SAGE and RACE. Using this approach, I have been able to identify a localization element responsible for NGF-dependent localization of the IMPA1 mRNA. I am now working on a follow-up project founded on a novel and revolutionary mechanism that controls local translation in axons. My most recent data show that the 3’UTRs of neuronal transcripts undergo post-transcriptional remodelling and suggest an alternative mechanism for regulation of local protein synthesis.

Academic Background
2000   Doctor of Philosophy Universita degli Studi di Roma
1995   Laurea Universita degli Studi di Pisa
Some IRIS profile information is sourced from HR data as explained in our FAQ. Please report any queries concerning HR data shown on this page to hr-services@ucl.ac.uk.
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by