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Prof Caroline Sabin
Royal Free Campus
Rowland Hill Street
Fax: 020 7794 1224
Prof Caroline Sabin profile picture
  • Professor of Medical Statistics and Epidemiology
  • Infection & Population Health
  • Institute for Global Health
  • Faculty of Pop Health Sciences

In 2000 I initiated the UK Collaborative HIV Cohort (UK CHIC) Study, a major multicentre study of >30,000 HIV-infected individuals in the UK. I am the principal investigator for the study, which is one of the largest clinical cohorts of HIV-infected individuals worldwide.  The network of clinicians participating in the study includes key opinion leaders from the UK, ensuring that results from the study are fed back to clinicians and into national and international treatment guidelines. 

I recently initiated a unique multi-agency initiative, involving the National Health Service, the Health Protection Agency, the MRC Clinical Trials Unit, academia and the patient community/advocacy groups (the DHICE Initiative), which aims to develop a UK platform for integrated clinical and research data.  This will permit us to address important research and translational questions relating to HIV care in the UK, and so enhance the quality of care for those living with HIV. 

Since 2001, I have been the principal statistician for the D:A:D (Data collection on Adverse events of anti-HIV Drugs) study, a large international multi-cohort study of >33,000 HIV-infected individuals which aims to describe the relationship between antiretroviral drugs and cardiovascular disease (although will be expanded to include other clinical endpoints from 2010 onwards).  I co-lead this project with collaborators in Copenhagen, provide advice on the strategic direction of the programme of research, and liaise with the funding body (including representatives from the US Food and Drug Administration (FDA), the European Medicines Evaluation Agency (EMEA), the pharmaceutical industry and HIV patient community).    

I have been closely involved with many other large HIV cohort studies and collaborations, both in the UK and abroad.  I am a member of the Scientific Oversight Workpackage for the EuroCoord collaboration – this is a major collaborative effort that involves all cohorts of HIV-infected persons in Europe (with information on >250,000 infected individuals).   

Research Summary

My research interests focus on describing the natural history of infection and identifying prognostic markers for disease progression, in describing response to antiretroviral therapy and identifying factors associated with this, and in describing the frequency of and factors associated with adverse events of antiretroviral therapy.  In all aspects of this work, I collaborate closely with clinicians in order that the work has clinical relevance and to ensure that, where possible, any outputs can be translated into improvements in clinical care.  I present regularly on the benefits and limitations of cohort studies, particularly when making treatment comparisons and am currently working on approaches to reduce bias when comparing the incidence of adverse events across different trials and cohorts.

Teaching Summary

I taught medical statistics and epidemiology at the Royal Free Hospital annually from 1992-2007. Over that time, I was a tutor on the Biometry (course lead 2000-2001), Population Studies, Communication and Learning Skills, and Evaluation of Evidence (Site lead 2001-1008) courses, and a member of the Curriculum Development Committee for the 'Evaluation of Evidence' vertical spine.  I have been a tutor on several MSc. courses, have supervised 12 doctoral students, and was the Departmental Graduate Tutor from 2007-2010.  I am a regular PhD examiner, both within UCL and externally (UK and international).  I have been a member of the UCL Biostatistics Strategy Group, one of the aims of which is to increase the reputation of UCL as a centre for biostatistics teaching. 

With Dr Aviva Petrie, I am co-author of a best-selling textbook, Medical Statistics at a Glance, the third edition of which was published in 2009.  This book has been modified substantially since the first edition so that it continues to meet the needs of the current medical school curriculum. An accompanying workbook will be published by Wiley-Blackwell in January 2013.

I have developed and am the Course leader on an annual four-day ‘Research Methods for HIV Research’ course, which now attracts participants from research, clinical and industry backgrounds across Europe.  Along with Dr P Mallon (University College Dublin), I co-ordinate the SpRITE course, a three-day intensive training program in Research Methods for Specialist Registrars in the HIV field, sponsored by Gilead Sciences.  I also co-ordinate a series of Critical Appraisal Workshops (with Bristol-Myers Squibb), aimed at increasing the statistical/epidemiological knowledge of junior doctors prior to their consultant interview.  In addition, I have developed a series of training courses for collaborators in Eastern/Central Europe that aim to build research capacity in these countries, and many one-day training sessions on HIV epidemiology and medical statistics for research nurses, pharmacists, junior doctors and the HIV patient community.


Academic Background
1995   Doctor of Philosophy University of London
1991   Master of Science University of Leicester
1988   Bachelor of Science (Honours) University of Bath
1988   Undergraduate Degree University of Bath
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