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Dr Carlos Flores
Centre for Urological Biology, Research Dpt of Renal Medicine, Division of Medicine
UCL, Royal Free Hospital Campus, Rowland Hill Street
London
NW3 2PF
Dr Carlos Flores profile picture
Appointment
  • Research Fellow
  • Renal Medicine
  • Div of Medicine
  • Faculty of Medical Sciences
Biography

After completion of a BSc in Biology and MSc in Molecular and Cell Biology (both class A in the European Credit Transfer and Accumulation System (ECTS) framework), I did a PhD in Cell and Molecular Biology in collaboration between the Bioengineering and Synthetic Microbiology group, i3S-Institute for Research and Innovation in Health (Portugal) and University of Florence (Italy), that finished in 2019. Some of the work was awarded by learned microbiology societies (FEMS and SPM). During 2020, before applying for my current Postdoctoral position, I contributed to the COVID-19 emergency response in Portugal, as lab technician volunteer in the Pathology department, Hospital Center of Vila Nova de Gaia.

 

My research have been mainly focused in the Cell and Molecular Microbiology field with particular interest on biotechnology/drug development, bacterial physiology and interaction with external environment, but in strong collaboration with bioengineering, eukaryotic cell biology and biochemistry groups. This path led to the publication of 10 manuscripts (6 as first author), and the organization/participation of several scientific dissemination events. During this journey I frequently left my comfort zone, which allowed me to acquire a vast set of skills and background in both basic and applied science. Altogether, my interests and skills led me to the infection biology field, specifically host-bacteria interaction, which is the path that I want to pursue in my future research.

Research Groups
Research Themes
Research Summary

Having in mind that urinary tract infections (UTIs) are among the most common, and understudied, healthcare infections worldwide, I am currently trying to understand the pathophysiological mechanisms underlying host-uropathogen interactions. These infections commonly have a suboptimal or inefficient treatment, which lead to frequent recurrence and major contribution for the global antimicrobial resistance (AMR) crisis. To tackle these issues, I am developing human cell-based systems, such as organoids/organ-on-chip and evaluate their response to infection. On the other hand, I am also assessing the cell and molecular pathways that allow uropathogens to persist and reinfect the urinary tract. 

My ultimate goal is to establish reliable platforms for the study of the uropathogen infection strategies and for the development of innovative therapeutics.

Teaching Summary

I have prepared and delivered two hands-on workshops for biomedical undergraduate and MSc students (University of Porto, Portugal). 

I supervised the thesis from 1 MSc student (Biochemistry course, Sep. 2019-Nov. 2020, University of Porto, Portugal), and I am currently supervising 1 MSc student (Drug Design MRes, UCL) and 2 undergraduate students (iBSc Clinical Sciences and Applied Medical Sciences degree courses, UCL).

Appointments
MAR-2020 – JUL-2020 Volunteer as lab technician (SarsCoV-2 taskforce team) Pathology Hospital Center of Vila Nova de Gaia, Portugal
NOV-2019 – JAN-2020 Research Fellow Bioengineering & Synthetic Microbiology group i3S - Institute for Research and Innovation in Health, Portugal
MAR-2015 – MAR-2019 PhD Fellow Bioengineering & Synthetic Microbiology group i3S, Portugal & University of Florence, Italy, European Union
MAR-2014 – FEB-2015 Research Fellow   IBMC - Institute for Molecular and Cell Biology, Portugal
SEP-2012 – SEP-2013 Master's Student Microbial Ecophysiology group CIIMAR & FCUP -Faculty of Sciences, University of Porto, Portugal
SEP-2010 – JUN-2011 Internship Microbiology ICBAS-Institute of Biomedical Sciences Abel Salazar, UP, Portugal
Academic Background
  BSc Biology  
  MSc Cell and Molecular Biology  
  PhD Molecular and Cell Biology  
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