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Dr Christos Proukakis
3B-73, Upper 3rd floor
Clinical Neuroscience, Royal Free Campus
Rowland Hill Street
  • Senior Clinical Lecturer
  • Clinical and Movement Neurosciences
  • UCL Queen Square Institute of Neurology
  • Faculty of Brain Sciences

After general medical training and MRCP, I completed a PhD at the Clinical Neurosciences department on the genetics and cell biology of the SPAST gene / spastin protein, the commonest gene mutated in hereditary spastic paraplegia (HSP). In parallel, I collaborated in work that led to the discovery of novel genes for HSP and related disorders.
My neurology specialist training was completed in and around London (Queen Square, King's, St Thomas', Hurstwood Park), with experience including neurogenetics, movement disorders, dementia, intensive care, motor neuron disease.
I have been a Senior Lecturer in Clinical Neuroscience and Consultant Neurologist at the Royal Free and Chase Farm hospitals since November 2009. In addition to general neurology, I see outpatients with Parkinson's disease and genetic disorders including HSP.

Research Themes
Research Summary

My current research is focused on the genetics of Parkinson's disease, in particular the hypothesis of somatic mutations having a role. We are currently investigating this with a range of techniques designed to detect mosaicism for different types of mutations. This is in the context of the recent revolution in our understanding of mosaicist in the brain.


 I have also identified and studied a novel SNCA (alpha-synuclein) mutation (H50Q). 

 I have been awarded grants as principal investigator by the Royal Free Peter Samuel Fund, Parkinson's UK, and the Michael J Fox foundation for the work above.

A summary of my current research is shown in this talk, given to the Royal Free 2015 alumni meeting


Teaching Summary

I lecture on the pathogenesis of Parkinson's disease on the MSc Clinical Neuroscience / Clinical Neurology course. I am also on the programme committee for the latter, and on the Translational Neuroscience MRes.

I also lecture on HSP and CAG repeat disorders for BSc final year students.

I teach movement disorders to clinical medical students during their neurology rotation.

Laboratory teaching and supervision currently of MRes students and currently one PhD student and one Post-doctoral research associate. Informal teaching on inpatients, and ad hoc seminars, to junior medical staff.

01-OCT-2018 Associate Professor Clinical and Movement Neurosciences UCL, United Kingdom
Academic Background
2009 CCST Certificate of Completion of Specialist Training – Neurology General Medical Council
2009 PhD Doctor of Philosophy – Molecular Biology and Genetics University of London
1997 MRCP Member of the Royal College of Physicians – Medicine Royal College of Physicians
1994 BM BChir Bachelor of Medicine/ Bachelor of Surgery – Medicine University of Oxford
1991 BA Bachelor of Arts – Natural Sciences University of Cambridge
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