Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Dr Cayman Williams
3rd floor
Institute of Immunity and Transplantation
Rowland Hill Street
Dr Cayman Williams profile picture
  • Research Fellow
  • Div of Infection & Immunity
  • Faculty of Medical Sciences
My BSc in Biological Science and MSc in Biomedical Science were both completed at Edinburgh Napier University in 2015 and 2016 respectively.  

From 2017-2021 I had the privilege of undertaking my PhD with Prof David Sansom within the Institute of Immunity and Transplantation at University College London. We investigated the different roles of CD28 co-stimulation in human Memory and Naive T cells and developed assays to measure variation in T cell activation thresholds between healthy humans. We also studied the immunoregulatory receptor, CTLA4, addressing functional questions such as how this receptor regulates CD28 co-stimulation and why there are two ligands (CD80 and CD86) that these receptors engage with.

In 2022 I joined Prof Benedict Seddon's group as a Postdoctoral Research Associate, also at the Institute of Immunity and Transplantation. Currently, we are investigating how CD28 and CTLA4 function impacts the kinetics of Memory T cell development in adult and neonatal mice. 

Research Themes
Research Summary

During my PhD and Postdoctoral work, I developed in vitro assays to investigate TCR and CD28 activation thresholds in different human T lymphocyte subsets. I also studied how CD28 and TCR signals 'intertwine' to modulate cell-specific functions in Memory and Naive CD4+ T cells.   

I have also investigated the biological function of CTLA4 in human Tregs, focusing on how perturbations in ligand-receptor interactions impact CTLA4's regulatory capability. 

Using mouse genetics, I have also been investigating how CD28 and CTLA4 impact the developmental kinetics of T cell memory in vivo in the neonatal and adult setting. 

These investigations provide novel insight into the basic immunology of CD28 and CTLA4 function which will enhance our understanding of T cell mediated disease and how to improve future therapies to treat them.  

Teaching Summary
Module INIM0011 - Lecture titled 'Progress in understanding and treatment of autoimmune disease'

I supervise lab placements for;

BSc, iBSc, MSc & MRes students 

Academic Background
  MSc Biomedical Sciences  
  BSc Hons Biological Sciences  
  PhD Immunology  
Some IRIS profile information is sourced from HR data as explained in our FAQ. Please report any queries concerning HR data shown on this page to hr-services@ucl.ac.uk.
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by