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Dr Cynthia Yu Wai Man
UCL Institute of Ophthalmology & Moorfields Eye Hospital
11-43 Bath Street
London
EC1V 9EL
Appointment
  • NIHR UCL BRCs/ Francis Crick Institute Clinical Research Training Fellow
  • Institute of Ophthalmology
  • Faculty of Brain Sciences
Biography

Dr Yu-Wai-Man is a Postdoctoral Research Fellow at the UCL Institute of Ophthalmology and a Honorary Fellow at Moorfields Eye Hospital. She graduated in medicine from the Newcastle University in 2005, after being awarded a British Council International Scholarship (2000-2005). During her undergraduate research at the Institute of Genetic Medicine, she has identified a novel heterozygous POLG2 mutation in autosomal dominant Progressive External Ophthalmoplegia. Dr Yu-Wai-Man became a Fellow of the Royal College of Ophthalmologists (London) in 2013. Dr Yu-Wai-Man was also an NIHR Francis Crick Institute Clinical Research Fellow at the UCL Institute of Ophthalmology and the Francis Crick Institute (2014-2017), and was awarded a EUREKA Fellowship in Translational Medicine in 2015.

Research Summary

Dr Yu-Wai-Man has identified a distinct fibrosis gene signature in the conjunctiva after glaucoma surgery. Understanding the dysregulated genes in ocular fibrosis will provide new mechanistic and biological insights into this complex multifactorial disease. It will also help to develop targeted therapies and novel small molecule therapeutics to prevent scarring in the eye. Dr Yu-Wai-Man has also set up a fibrosis biobank of ocular tissues and cell lines and is working on potential novel genetic biomarkers to develop a more personalised and stratified approach in anti-fibrotic ocular therapeutics.

Academic Background
2013 FRCOphth Fellow of the Royal College of Ophthalmologists – Ophthalmology Royal College of Ophthalmologists
2005 MBBS Bachelor of Medicine/Bachelor of Surgery – Medicine Newcastle University
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