The goal of my research is to understand how epigenetic mechanisms contribute to the development and function of the central nervous system. We would like also to understand how alteration of these mechanisms leads to brain disorders and diseases. We are interested to characterise function of histone chaperones in the central nervous system spanning their role in the development and function of the central nervous system, their activity on chromatin remodelling in a neural context and the characterisation of their molecular regulation. My research is currently focusing on understanding the role of the histone variant H3.3 chaperone DAXX in normal brain development and function. As DAXX, H3.3 and the DAXX-binding protein ATRX have been implicated in brain diseases such as paediatric glioma, we aim also to determine the function of DAXX in the pathogenesis of this cancer and to establish whether targeting DAXX can be used as a therapeutic approach to treat childhood brain tumours.