David Frost's research interests sit at the intersections of close relationships, stress, stigma, and health. His primary line of research focuses on how stigma, prejudice, and discrimination constitute minority stress and, as a result, affect the health and well-being of marginalized individuals. He also studies how couples psychologically experience intimacy within long-term romantic relationships and how their experience of intimacy affects their health. These two lines of research combine within recent projects examining same-sex couples' experiences of stigmatization and the resulting impact on their relational, sexual, and mental health.

David is an Associate Editor for Annals of Behavioral Medicine (Oxford) and a Consulting Editor for Psychology of Sexual Orientation and Gender Diversity (American Psychological Association).