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Prof Daniel Gale
1/699, 1st Floor
UCL Department of Renal Medicine
Royal Free Hospital
Prof Daniel Gale profile picture
  • Professor of Nephrology
  • Renal Medicine
  • Div of Medicine
  • Faculty of Medical Sciences

Daniel Gale undertook medical training at Cambridge University, moved to London for postgraduate training (including a PhD under the supervision of Patrick Maxwell) and is now St Peter’s Chair of Nephrology at University College London. He runs the translational renal genetics service for North/Central London at the Royal Free Hospital and participates in the care of renal inpatients at the Royal Free Hospital. Prof Gale is an Honorary Consultant in Genomic Medicine at Great Ormond Street Hospital where he is Rare Diseases lead for the North Thames Genomic Laboratory Hub (which delivers genomic testing to around 10% of the UK population) and he also directs RaDaR, the UK Rare Renal Disease Registry.

Research Groups
Research Summary

I conduct research into genetic kidney disease and run the genetic kidney disease clinical service for North London that provides care for patients and families with hereditary kidney problems, including Polycystic Kidney Disease, Alport Syndrome, complement disorders and unexplained familial kidney failure. This service has pioneered the use of genomic testing for people with kidney disease, and patients are frequently offered enrolment in clinical research studies, including those involving new treatments.

Using linkage mapping, genome sequencing and other techniques I discovered and identified the underlying genetic causes of the diseases HIF2α erythrocytosis with pulmonary hypertension, which results from a defect in cellular oxygen sensing, and CFHR5 nephropathy, which results from a defect of complement alternative pathway regulation and which is endemic in people of Cypriot ancestry. I also study genetic factors important in other kidney diseases and, using genome wide association studies, have identified genes important in disorders including IgA nephropathy, MPGN/C3 glomerulopathy and Steroid Sensitive Nephrotic Syndrome.  I direct RaDaR, the UK Rare Renal Disease Registry (www.rarerenal.org) that now has almost 30,000 participants, and lead the UK-wide consortium that aims to interpret genomic data from the thousands of people with kidney disease participating in the 100,000 Genomes Project.

Within the UCL Department of Renal Medicine I hold the St Peter's Chair in Nephrology and lead the Centre for Genetics and Genomics (https://www.ucl.ac.uk/nephrology/research/centre-genetics-and-genomics). Research in the Centre aims firstly to discover genetic causes of and contributors to kidney disease; secondly to understand the underlying biological mechanisms; and thirdly to use this knowledge to develop and improve treatments. 

Academic Background
2010   Doctor of Philosophy University College London
2002   Master of Arts University of Cambridge
2000   Bachelor of Medicine University of Cambridge
2000   Bachelor of Surgery Degree University of Cambridge
1998   Bachelor of Arts University of Cambridge
  FRCP Fellow of the Royal College of Physicians  
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