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Dr Daniel Gale
2/6003, 2nd Floor
UCL Centre for Nephrology
Royal Free Hospital School of Medicine
London
NW3 2PF
Tel: 0207 317 7589
Appointment
  • Senior Clinical Research Fellow/ Honorary Consultant
  • Nephrology
  • Div of Medicine
  • Faculty of Medical Sciences
Research Summary

I conduct research into genetic kidney disease and perform a weekly nephrology clinic specializing in the care of patients and families with hereditary kidney problems, including polycystic kidney disease, unexplained familial kidney failure, inherited microscopic haematuria syndromes and renal cancer syndromes.

Using linkage mapping, next generation sequencing and other techniques I have described and identified the molecular defects responsible for the genetic diseases HIF2α erythrocytosis, which results from a defect in cellular oxygen sensing, and CFHR5 nephropathy, which results from a defect of complement alternative pathway regulation and which is endemic in people of Cypriot ancestry.

Ongoing projects aim firstly to improve understanding of the pathophysiology of these diseases; secondly to develop rational approaches to their treatment; and thirdly to investigate other families with inherited kidney disease in order to uncover the genetic change responsible in each one.

Academic Background
2010 PhD Doctor of Philosophy – Medicine/Nephrology/Molecular Biology University College London
2002 MA Master of Arts – Arts University of Cambridge
2000 MB Bachelor of Medicine – Medicine University of Cambridge
1998 BA Bachelor of Arts – Developmental Neurobiology University of Cambridge
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