UCL  IRIS
Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at http://www.ucl.ac.uk/finance/research/post_award/post_award_contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Prof Daniel Gale
1/699, 1st Floor
UCL Department of Renal Medicine
Royal Free Hospital
London
NW3 2PF
Appointment
  • Professor
  • Renal Medicine
  • Div of Medicine
  • Faculty of Medical Sciences
Role
UCL Subsidiary Supervisor
Research Groups
Research Summary

I conduct research into genetic kidney disease and run the genetic kidney disease clinical service for North London that provides care for patients and families with hereditary kidney problems, including Polycystic Kidney Disease, Alport Syndrome, complement disorders and unexplained familial kidney failure. Patients are frequently offered enrolment in clinical research studies, including those involving new treatments.


Using linkage mapping, next generation sequencing and other techniques I discovered (and identified the genetic defects responsible for) the diseases HIF2α erythrocytosis and pulmonary hypertension, which results from a defect in cellular oxygen sensing, and CFHR5 nephropathy, which results from a defect of complement alternative pathway regulation and which is endemic in people of Cypriot ancestry. I also study genetic factors important in other kidney diseases and, using genome wide association studies, have identified genes important in disorders including IgA nephropathy, MPGN/C3 glomerulopathy and Steroid Sensitive Nephrotic Syndrome.  I chair the Renal Association Rare Renal Disease Registry (www.rarerenal.org) and lead the UK-wide consortium that aims to interpret genomic data from the thousands of people with kidney disease participating in the 100,000 Genomes Project.


Within the UCL Department of Renal Medicine I lead the Centre for Genetics and Genomics (https://www.ucl.ac.uk/nephrology/research/centre-genetics-and-genomics). Research in the Centre aims firstly to discover genetic causes of and contributors to kidney disease; secondly to understand the underlying biological mechanisms; and thirdly to use this knowledge to develop and improve treatments. 


Academic Background
2010   Doctor of Philosophy University College London
2002   Master of Arts University of Cambridge
2000   Bachelor of Medicine University of Cambridge
2000   Bachelor of Surgery Degree University of Cambridge
1998   Bachelor of Arts University of Cambridge
Please report any queries concerning the data shown on this page to https://www.ucl.ac.uk/hr/helpdesk/helpdesk_web_form.php
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by