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Prof Dan Jagger
UCL Ear Institute
332 Gray's Inn Rd
London
WC1X 8EE
Prof Dan Jagger profile picture
Appointment
  • Professor of Cell Physiology
  • The Ear Institute
  • Faculty of Brain Sciences
Biography

I am primarily a physiologist, and my main interests are in the homeostasis and development of inner ear “hair cells”, and the function of cells in the auditory nerve.  

I collaborate with a number of labs nationally and internationally. 

My work focuses on the identification of potential therapeutic approaches for hearing loss and balance disorders.

Research Summary

I’m interested in the proteins that make cochlear cells work, particularly those in supporting cells that look after cochlear hair cells and neurons. Hair cells can’t regenerate; if you damage them they’re gone
forever. They have to be kept in great condition for a lifetime. The supporting cells remove any nasty substances from the environment around hair cells to keep them happy. By understanding how supporting cells do their job, we can begin to develop therapies that could help all of us to keep our hair cells for longer.

In other research, I have a growing interest in the hearing impairment observed in certain “ciliopathies”, such as Alström syndrome. It is not currently obvious how mutations in proteins involved in the function of the cilium can cause loss of hair cells.

Areas currently under investigation:

  • The characteristics of gap junctions in the inner ear
  • The effects of connexin mutations on cochlear physiology
  • The development of afferent neurons in the cochlea
  • The contribution of cilia proteins to cochlear development
Teaching Summary

I currently contribute to postgraduate teaching at the Ear Institute, and coordinate module EARI0008 "Anatomy & Physiology of the Audio-Vestibular System".
Academic Background
1996   Doctor of Philosophy University of Bristol
1993   Bachelor of Science (Honours) University of Newcastle upon Tyne
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