My research is aimed at understanding the pathophysiology of the placental disorders pre-eclampsia and fetal growth restriction in order to design an effective prophylaxis and treatment. My group use in vivo methods to study maternal vascular physiology and ex vivo models to study micro-vessel reactivity.
We have contributed to the observations that women who have had pre-eclampsia are at increased risk of future cardiovascular disease and men who father growth restricted offspring are more likely to be insulin resistant. Ongoing work is aimed at understanding the inheritance of an insulin resistant genotype from parent to growth restricted offspring.

I am chief clinical investigator on the MRC funded Stamp trial, investigating the possibility that statins may be beneficial in ameliorating pre-eclampsia.

Other projects are aimed at understanding the pathophysiology of other gestational syndromes and how they predict a woman's future health.