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Dr David Cash
Appointment
  • Senior Research Associate
  • Neurodegenerative Diseases
  • Institute of Neurology
  • Faculty of Brain Sciences
Biography
I obtained my Bachelor’s Degree from Duke University in Biomedical Engineering in 1997, followed by a MS and PhD from Vanderbilt University in 2000 and 2004 respectively, also in Biomedical Engineering. After a postdoctoral fellowship at CMIC in 2005 and 2006, I went to work in the private sector at a start-up company called IXICO Ltd., where I ran the imaging in multiple large scale studies and trials in Alzheimer’s and Huntington’s disease. I returned to UCL in a joint position between the Dementia Research Centre and CMIC in 2011. 
Research Summary
My research focus is on imaging biomarkers, particularly during the pre-symptomatic phase of dementias. The goal is to determine when and where changes are occurring in patients before symptoms occur so as to design appropriate measurements to track disease progression and potential signs of disease modification during a therapeutic trial. The most common imaging measurements include volumetric T1 MRI in order to track changes in the size and shape of various brain structures, both cross-sectionally and in more sensitive measures of longitudinal change. However, we are often incorporating more advanced MR imaging techniques, such as diffusion weighted imaging, resting state fMRI, and arterial spin labelling to identify other changes in the brain. My role is to help translate novel biomarkers on these modalities into more clinical use at the Dementia Research Centre, so that we can determine how best to use these in large scale, multi site studies.
Academic Background
2004 PhD Doctor of Philosophy – Biomedical Engineering Vanderbilt University
2000 MS Master of Science – Biomedical Engineering Vanderbilt University
1997 BSE Bachelor of Science and Engineering – Biomedical Engineering and Electrical Engineering Duke University
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