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Prof Dimitri Michael Kullmann
Queen Square House
Queen Square
Tel: 020 3448 4100
Fax: 020 7278 5616
  • Professor of Neurology
  • Clinical & Experimental Epilepsy
  • UCL Queen Square Institute of Neurology
  • Faculty of Brain Sciences

I studied Physiological Sciences (undergraduate Medicine) at Oxford University and obtained a DPhil in the laboratory of Julian Jack before resuming my clinical studies at St Thomas' Hospital (London). I then alternated between research in synaptic trasnsmission  (including a couple of years with Roger Nicoll, UCSF) and postgraduate medical training in London until I established my own laboratory at the Institute of Neurology in 1992.

Research Themes
Research Summary

My interests span the fundamental mechanisms of synaptic transmission, the computational properties of small neuronal circuits, and alterations in neuronal and circuit excitability in epilepsy and other neurological disorders. The core methods in my lab are in vitro electrophysiology and pharmacology, but we also apply confocal and two-photon laser scanning microscopy, computational simulations, molecular genetic methods, and heterologous expression of mutated ion channels.

I collaborate with Michael Hanna, Henry Houlden, Stephanie Schorge and others to understand the mechanisms of inherited neurological diseases caused by mutations of ion channels (channelopathies).

My laboratory has contributed to the discovery of silent synapses, glutamate spillover, presynaptic GABAA receptors in the cortex, human epilepsy caused by K+ and Ca2+ channel mutations, tonic inhibition in the hippocampus, and Hebbian and anti-Hebbian LTP in hippocampal interneurons.

One of our goals is to understand how phenomena that we have studied at the cellular level (synaptic, extra-synaptic and non-synaptic signalling, different types of long-term potentiation) interact to regulate the excitability of small neuronal circuits. We are also integrating our studies on hippocampal circuit function with knowledge of how interneurons and principal cells fire during different behaviours. This is being approached with a synthesis of experiments and computational simulations. 

In collaboration with Matthew Walker, Stephanie Schorge, Rob Wykes and Dennis Kaetzel, my laboratory has developed several promising strategies for gene therapy of focal epilepsy.

Teaching Summary

I lecture on MSc courses at the Institute of Neurology, and to undergraduates studying Neuroscience at UCL. I also supervise PhD students through the UCL 4-year programme in Neuroscience, as well as students on the Brain Research Trust/MRC-funded programme in clinical neuroscience. 

01-AUG-1997 – 31-JUL-2007 MRC Senior Clinical Fellow Institute of Neurology UCL, United Kingdom
01-AUG-1992 – 31-JUL-1997 MRC Clinician Scientist Fellow Clinical Neurology Institute of Neurology, United Kingdom
01-NOV-1990 – 31-JUL-1992 Postdoctoral Research Fellow Pharmacology UC San Francisco, United States
01-FEB-1990 – 31-OCT-1990 Registrar, Medicine Medicine Edgware General Hospital, United Kingdom
01-AUG-1989 – 31-JAN-1990 Senior House Officer, Neurology Neurology National Hospital for Neurology & Neurosurgery, United Kingdom
01-FEB-1989 – 31-JUL-1989 Senior House Officer, Medicine Medicine Hammersmith Hospital, United Kingdom
01-AUG-1987 – 31-JAN-1989 Nuffield Medical Research Fellow Physiology Oxford University, United Kingdom
01-OCT-1982 – 30-SEP-1983 Prize Fellow Magdalen College Oxford University, United Kingdom
Academic Background
2000 FRCP Fellow of the Royal College of Physicians – Medicine Royal College of Physicians
1990 MRCP Member of the Royal College of Physicians – Medicine Royal College of Physicians
1986 MBBS Bachelor of Medicine/Bachelor of Surgery – Medicine University of London
1984 DPhil Doctor of Philosophy – Physiological Science University of Oxford
1979 BA Hons Bachelor of Arts (Honours) – Physiological Science Balliol College, Oxford
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