During my PhD training and post-doctoral experience in Prof. Julian Downward's lab, I have focused on the study of cancer, from functional characterisation of cancer mutations to investigation of targeted ways of intervention. To this aim, I employed a variety of approaches, including cellular and mouse models, and high or low-throughput screening methods designed to answer specific biological questions. My work unveiled targetable vulnerabilities in a G proteins-centred signalling network in PTEN-deficient triple-negative breast cancers.

More recently, under supervision of Prof. Veronica Kinsler, I have been applying my experience to molecular characterisation and identification of therapeutic targets for rare mosaic genetic diseases. I’ m translating my knowledge of aberrant G protein signalling to the study and treatment of Sturge Weber Syndrome, caused by mutations in G protein-coding genes. My research is also currently focusing on identifying therapeutic vulnerabilities in melanoma occurring in CMN (Congenital melanocytic nevi) patients, an inoperable and lethal disease caused in most cases by mosaic mutations on NRAS gene.