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Dr Emmanuel Boucrot
Room 102
Department of Structural and Molecular Biology
Darwin Building , Gower Street
London
WC1E 6BT
Tel: Extn 34302
Appointment
- Associate Professor
- Structural & Molecular Biology
- Div of Biosciences
- Faculty of Life Sciences
Biography
2019 - 2021 Career break (family reasons)
2018 Wellcome Trust Birkbeck Institutional Strategic Support Fund Career Development Award
2017 Fellow of the Royal Society of Biology (FRSB)
2016 Associate Professor in Molecular Cell Biology
2015 Fellow of the Higher Education Academy (FHEA)
2014 Lister Institute Research Prize
2011 - 2016 BBSRC David Phillips Research Fellow, University College London, London (UK)
2008 - 2011 MRC Career Development Fellow, MRC Laboratory of Molecular Biology, Cambridge (UK)
2006 - 2008 HFSP Postdoctoral Fellow, Harvard Medical School, Boston (US)
2005 - 2006 EMBO Postdoctoral Fellow, Harvard Medical School, Boston (US)
2001 - 2005 PhD in Immunology, University of Aix-Marseille II, Marseille (France)
Publications: 29 research papers, 9 review articles. h-index 26, over 7,000 citations
Selected research papers:
- Chan Wah Hak L et al. and Boucrot E$ (2018) 'FBP17 and CIP4 recruit SHIP2 and Lamellipodin to prime the plasma membrane for Fast-Endophilin-Mediated Endocytosis' Nat Cell Biol 20 (9) pp.1023-31
- Boucrot E$ et al. (2015) 'Endophilin marks and controls a clathrin-independent endocytic pathway' Nature 517 (7535) pp.460-5
- Boucrot E* et al. (2012) 'Membrane fission is promoted by insertion of amphipathic helices and is restricted by crescent BAR domains' Cell 149 (1) pp.124-36
- Henne WM*, Boucrot E*,$ et al. (2010) 'FCHo proteins are nucleators of clathrin-mediated endocytosis' Science 328 (5983) pp.1281-4
- Boucrot E et al. (2005) 'The intracellular fate of Salmonella depends on the recruitment of kinesin' Science 308 (5725) pp.1174-8
* joint first authors $ corresponding author
Research Groups
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Research Summary
Understanding molecular mechanisms and establishing functions of intracellular membrane trafficking in health and disease.
Current Project: Mechanisms of fast endophilin-mediated endocytosis (FEME)
Endocytosis is the process by which cells acquire substances from the extracellular space and internalise transmembrane cell surface proteins, of which receptors are a major class. The process occurs through invaginations of the plasma membrane forming endocytic vesicles that, once pinched off the surface, are transported to endosomes and, from there, sorted to the appropriated cellular destinations depending on the fate of the receptor. We recently identified a new pathway of endocytosis, the Fast Endophilin-Mediated Endocytosis (FEME) pathway (Boucrot et al. 2015 Nature; Renard et al. 2015 Nature; Chan Wah Hak et al. 2018 Nat Cell Biol). Our goal is to establish the functions and molecular mechanisms of this novel route of entry into cells.
This project is funded by a 2014 Lister Institute Research Prize
Current group members:
Ms Alessandra Casamento (PhD student funded by BBSRC)
Mr Shaan Subramanian (PhD student funded by MRC)
Alumni: Ms Claudia Hinze (PhD student to graduate 2018, now PDRA at UCL), Dr Antonio PA Ferreira (PhD student 2011-2016, now PDRA at Harvard University, US), Dr Kieran McGourty (PDRA, 2012-2016, now Lecturer at U. of Limerick, IRL), Dr Ana Mendes Pereira (PDRA, 2012-2016, now Senior Scientific Officer at King's College London, UK),
Teaching Summary
Career break until 2021 (family reasons)
Academic Background
| 1998 | BSc | Bachelor of Science – Biochemistry | Universite de Genève |
| FHEA | ATQ03 - Recognised by the HEA as a Fellow | ||
| 2005 | PhD | Doctor of Philosophy – Immunology | Universite de la Mediterranée (Aix Marseille II) |
| 2001 | MRes | Master of Research – Immunology | Universite de la Mediterranée (Aix Marseille II) |
| 2000 | MSc | Master of Science – Biochemistry | Universite de Genève |
