Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Dr Emily Eden
Institute of Ophthalmology, 11-43 Bath Street
Dr Emily Eden profile picture
  • Lecturer
  • Institute of Ophthalmology
  • Faculty of Brain Sciences
Research Summary

Endocytic and phagocytic pathways introduce huge amounts of material into cells that are ultimately degraded within the lysosome. Cholesterol derived from internalized material, is transported from the lysosome to the ER. This delivery of cholesterol to the ER is a critical step in maintaining cholesterol homeostasis. 

We have shown that the lysosome and the ER form transient connections where the membranes of the two organelles are physically associated.  These connections, known as membrane contact sites, allow exchange of material and protein-protein interactions between the two organelles.  We are trying to identify the proteins involved in regulating these contact sites and to understand the relationship between lipid transport and the ER-lysosome interface.

Defects in lipid transport result in lipid accumulation in lysosomes that is associated with several neurodegenerative diseases, including a rare but devastating childhood lysosomal storage disease, Niemann Pick type-C (NPC). Lipid accumulation is also believed to be a major contributing factor to the development of Age-related Macular Degeneration (AMD), the most common cause of vision loss in the elderly. 

By learning more about the regulation of ER-lysosome contact sites and their role in lipid transport, we aim to identify tools with which to mobilise lipids from the lysosome to alleviate lysosomal storage defects in diseases such as NPC and AMD.

01-APR-2020 Non-Clinical Lecturer Institute of Ophthalmology UCL, United Kingdom
Academic Background
2019   ATQ02 - Recognised by the HEA as an Associate Fellow University College London
2003   Doctor of Philosophy Imperial College of Science, Technology and Medicine
Some IRIS profile information is sourced from HR data as explained in our FAQ. Please report any queries concerning HR data shown on this page to hr-services@ucl.ac.uk.
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by