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Prof Liz Jury
4th Floor Room 415
Rayne Building
5 University Street
Tel: 020 3108 2154
Prof Liz Jury profile picture
  • Professor of Experimental Rheumatology
  • Inflammation
  • Div of Medicine
  • Faculty of Medical Sciences

Prof Jury started her career at St Bartholomew’s Hospital, London developing the Immunopathogology service specialising in the diagnosis of autoimmunity, immunodeficiency and immunophenotyping. She moved to a more research focused career joining Prof David Isenberg’s team in 2000 and now leads her own research group within the Centre for Rheumatology Research at University College London. Prof Jury’s work has developed new areas of research into signalling abnormalities in T and B cells from patients with systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis and Sjogren's syndrome making a significant contribution towards understanding the nature of these abnormalities, how they relate to disease pathogenesis and how they can be used to predict response to therapy.

Research Summary

A main focus of Prof Jury's research is to understand how changes in cellular and serum lipid metabolism influence immune cell function in human health and autoimmunity. Prof Jury was one of the first to identify plasma membrane lipid defects in T lymphocytes from patients with the autoimmune disease systemic lupus erythematosus (SLE) (Jury EC. 2003 Arthritis Rheum; Jury EC. 2004, J Clin Invest). She revealed that these defects contributed to immune cell hyperactivity and that by manipulating lipid (cholesterol and glycosphingolipid) biosynthesis some of the characteristic immune cell signalling and functional defects associated with SLE pathogenesis were reversed (Jury EC. 2006, J Immunol;  McDonald G, 2014, J Clin Invest). More recently her group has identified defects in lipid metabolism in people affected by multiple sclerosis (MS) (Waddington KE, 2019, BioRxiv). 

Prof Jury works in close collaboration with both clinicians and patients with the aim to improve diagnosis and treatment for people affected by autoimmunity (Robinson GA, 2019, Lupus). Current research projects are focused on using novel methods to stratify patient subgroups and to predict response to therapies (Adriani M, 2018. JCI Insight; Bradford CM, 2019, ACR Open Rheumatol; Robinson GA July 2019, medRxiv; Robinson GA, Sept 2019, medRxiv). 

Ongoing projects include:

1. Investigating the metabolic and immunological features contributing to immunogenicity in patients treated with biologic therapy.

2. Defining how gender influences immune responses in healthy and in female-biased autoimmunity.

3. Investigating how lipid metabolism defects influence disease progression in patients with MS.

4. Using metabolomic stratification to predict cardiovascular risk in patients with SLE (adult and juvenile-onset).

5. Using novel multi-omic stratification of patients with Sjogren's syndrome to improve treatment options.


Teaching Summary

·         Supervision of PhD students

·         Supervision of MRes, MSc and BSc student laboratory projects.

·         Personal tutor for Department of Medicine-organised MSc courses and MBBS  Programme.


Academic Background
2004   Doctor of Philosophy University of London
1998   Master of Science University of London
1984   IBMS Special Examination Institute of Biomedical Scientists
1982   Higher National Certificate Paddington College
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