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Dr Beth Payne
Paul O'Gorman Building
72 Huntley Street
Tel: +44 207 679 6591
Dr Beth Payne profile picture
  • Clinical Associate Professor
  • Research Department of Haematology
  • Cancer Institute
  • Faculty of Medical Sciences
Research Summary
Research Summary

The goal of our lab is to develop new models of hematopoietic diseases that will facilitate our understanding of their genetic basis and development of novel treatments using high throughput screening of whole organisms.

To this end we use the zebrafish model system.  Zebrafish are small, hardy freshwater fish that have the unique feature that their embryos are completely transparent. Blood development occurs extremely rapidly within the developing fish and all blood lineages identified in humans can also be found in zebrafish.  Furthermore the transcriptional programs that result in the generation of blood cells are highly conserved with that in mammals. Unbiased screens for abnormal blood development in zebrafish have resulted in the identification of genes that have subsequently been determined as disease genes in humans underscoring the power of this system. Our lab studies blood diseases including Diamond-Blackfan Anaemia and myelodysplastic syndrome.

MAY-2006 – DEC-2010 Clinical Research Fellow Pediatric Oncology Dana-Farber Cancer Institute, Harvard Medical School, Boston, United States
OCT-2004 – OCT-2005 Clinical Research Fellow National Heart and Lung Institute Imperial College, Hammersmith Campus, United Kingdom
MAY-2001 – APR-2006 Specialist Registrar in Haematology Haematology North West Thames, United Kingdom
AUG-1999 – JUN-2000 Senior House Officer Department of Medicine and Therapeutics Glasgow Western Infirmary, United Kingdom
AUG-1998 – AUG-1999 Senior House Officer Rotation General Medicine, Oncology, Respiratory Medicine Oxford Radcliffe Hospitals, United Kingdom
Academic Background
2011   Doctor of Philosophy Barts and The London Queen Mary's School of Medicine and Dentistry
1997   Bachelor of Medicine, Bachelor of Surgery University of Glasgow
1994   Bachelor of Science University College London
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