* Novel approaches for generation of antigen-specific T cells for leukaemia and cancer immunotherapy. * Retroviral gene transfer of T cell receptor (TCR) genes into T cells and haematopoietic stem cells to re-direct antigen-specificity. * The generation of MHC class I-restricted tumour antigen-specific CD4+ helper T cells to augment CD8+ T cell mediated tumour immunotherapy. * Analysis of functional avidity and signalling pathways of tumour antigen-specific TCRs. * Investigation of the role of the CD8 co-receptor in TCR transduced CD4+ helper T cells and conventional CD8+ T cells. * The generation of pre-clinical models for the evaluation of WT1-specific immunotherapy (WT1 is a tumour associated antigen over-expressed in myelodysplasia (MDS), leukaemias (AML, CML), breast, ovarian, prostate and colon cancers. * Isolation of TCRs from T cell clones specific for tumour antigens. * Generation of antigen-specific regulatory T cells using TCR gene transfer.