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Dr Edward Maguire
Appointment
  • Research Associate
  • Clinical & Experimental Epilepsy
  • UCL Queen Square Institute of Neurology
  • Faculty of Brain Sciences
Biography
Dr. Edward Maguire obtained a BSc (Hons) in Physiology and Pharmacology at the University of the West of England (2004), which included an industrial placement at Novartis, Basel Switzerland. He then worked for Merck Sharp and Dohme, Terlings Park, Harlow for one year researching new treatments for schizophrenia. Following this he obtained a PhD in neuroscience and pharmacology at Dundee University under the supervision of Dr. Delia Bellelli (2010), investigating inhibitory regulation of serotonergic dorsal raphe neurones by glycine and GABAA receptors. He then worked as a postdoctoral researcher in the labs of Prof. Jeremy Lambert and Dr. Delia Belelli, during this time he researched the role of GABAA  receptors in the nucleus accumbens in addiction and the interplay between stress and addictive behaviours. In 2014 he joined Prof. Mala Shah's lab to investigate the role of mitochondria motility in neuronal function.
Research Summary

Mitochondria are vital to normal neuronal function. Two major functions are the supply of energy in the form of ATP and to buffer Ca2+. Mitochondria move throughout neurones in order to supply energy and buffer Ca2+ in active zones, for example sites of synaptic neurotransmission. Thus, mitochondria motility is an important factor in the normal function of neurones. The aim of my research is to investigate the role of mitochondria motility in neuronal function, primarily utilising the technique of electrophysiology.

Academic Background
2010 PhD Doctor of Philosophy – Neuroscience and Neuropharmacology University of Dundee
2004 BSc Hons Bachelor of Science (Honours) – Physiology and Pharmacology University of West England
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