My research is devoted to understanding the role of genetic changes in cancer using as a model malignant hematological disorders. By searching for recurrent chromosome and gene abnormalities we aim to get insights into the events that lead to disease initiation and progression. These insights not only clarify the biology but also empower the diagnosis and treatment of these diseases.  My team pioneered the use of fluorescence in situ hybridization (FISH) for identification, quantification and chromosome localisation of gene rearrangements in leukemia thus contributing to the formulation of molecular cytogenetic techniques as an essential part of the diagnosis and management of leukemia. Current work includes several topics in Philadelphia positive disease including genomic array investigations of the evolution of blast crisis in CML, genome profile of acute and chronic BCR/ABL1 positive disease, genome aberrations associated with donor cell leukemia, factors influencing the development of resistance to tyrosine kinase inhibitors and the genomic profile of CD34(+) progenitor cells.