Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Prof Frank Kozielski
UCL School of Pharmacy
29-39 Brunswick Square
Prof Frank Kozielski profile picture
  • Professor of Pharmaceutical Chemical Biology
  • Pharma & Bio Chemistry
  • UCL School of Pharmacy
  • Faculty of Life Sciences

Frank studied Chemistry at the University Hamburg, Germany and the University Sevilla, Spain. He received his PhD from Hamburg University while working at the Max-Planck Working Groups for Structural Biology at Deutsches Elektron-Synchrotron (DESY) on the elucidation of the functional kinesin dimer. After his PhD he moved to France where he worked for 10 years at the French Atomic Commission (CEA) on human kinesins. In 2007 he joined the Beatson Institute for Cancer Research, Cancer Research UK, as a senior group leader and became professor at Glasgow Medical School. He was responsible for setting up the structural biology department used by several goups. In 2013 Frank was appointed Chair in Pharmaceutical and Biological Chemistry at the UCL School of Pharmacy in London. His current research interests involve members of the kinesin superfamily as potential targets for drug development.

Research Themes
Research Summary

Kinesins form a superfamily of proteins that fulfil key roles in intracellular transport and cell division. They use the energy derived from ATP hydrolysis to transport a variety of cargos directionally along microtubules but are also involved at crucial phases of the eukaryotic cell cycle, including bipolar spindle formation, chromosome congression, anaphase and cytokinesis. We are examining human kinesins and their associated proteins:


- Discovery, characterisation and development of small molecule inhibitors targeting human kinesins implicated in different diseases.


- Determination of kinesin-inhibitor complexes for subsequent structure-based design.


- Elucidation of the mechanism of action of kinesin-targeting drugs.


- Understanding the development of resistance against kinesin-targeting drugs, in vitro, in cell-based assays and ultimately in vivo.


- As a new area of research we aim to investigate kinesins involved in neurodegenerative diseases and viral transport.

Teaching Summary

MSc in Drug Discovery and Development

MSc in Drug Discovery and Pharma Management


Academic Background
2006   Habilitation Universite Joseph Fourier, Grenoble
1993   Doctor of Natural Sciences Universitat Hamburg
Some IRIS profile information is sourced from HR data as explained in our FAQ. Please report any queries concerning HR data shown on this page to hr-services@ucl.ac.uk.
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by