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Dr Gaby Captur
UCL Institute of Cardiovascular Science, MRC@LHA
1-19 Torrington Place, Fitzrovia, London
WC1E 7HB
Appointment
- Senior Clinical Lecturer
- MRC Unit for Lifelong Hlth & Ageing
- Population Science & Experimental Medicine
- Faculty of Pop Health Sciences
Biography
I am consultant cardiologist in inherited heart muscle conditions at the Royal Free London NHS Foundation Trust and senior lecturer at the UCL Institute of Cardiovascular Science.
Before completing my medical degree I was awarded the Texas Heart Institute prize for undergraduate writing by Denton Cooley at his ranch in Texas. I completed my medical degree (MD) in 2004 followed by MRCP and an MSc at the University of Brighton in 2007.
I moved to the UK for my cardiology training in 2010 working at The Heart Hospital, UCLH, Whittington Hospital and finally Barts Heart Centre as an academic trainee in the North East London Deanery.
I was awarded a PhD from UCL in 2013 for my work on left ventricular fractal analysis under the supervision of Professor James Moon and Professor Perry Elliott. During my PhD I was awarded the Yule Bogue research fellowship for a visiting residency at the US National Institute of Health and the Brigham's Women's Hospital in Boston. I was awarded the American Heart Association research prize in Dallas in 2013 and was runner up at the BCS congress in 2014 and at 6 other national and international CMR society meetings during this time.
In my last years of training at the Barts Heart Center I worked as a QMUL clinical lecturer, during which time I was also awarded a separate BRC post-doctoral research fellowship to support my mass spectrometry-based proteomics work in hypertrophic cardiomyopathy with Professor James Moon and Professor Perry Elliott at the Kevin Mills Biological Mass Spectrometry Laboratory. I subsequently became an NIHR Rare Disease Translational Research Fellow focusing on the deep phenotyping of lamin heart disease by CMR and multiomics at the Barts Heart Centre.
I became consultant and senior lecturer in 2018 and moved to the Royal Free, and to the UCL department of Experimental Medicine and Population Science.
I speak 4 languages, I am a keen and regular weekend golfer with a passion for the sea (swimming and motor yachts). I love to paint (oil on canvas, alla prima) and I am a daily runner.
Research Summary
Scientist.
I carry out my research within the MRC Unit for Lifelong Health and Ageing at UCL where we unravel the life-course epidemiology of cardiovascular diseases to inform public health.
As principal investigator of the BHF-funded MyoFit46 Programme we are conducting a perfusion-CMR / high-resolution ECGi epidemiological sub-study of the 1946 NSHD British Birth Cohort.
I lead the multicenter lamin DCM CMR phenotyping study that also includes a collaboration with Papworth Hospital and the Gurdon Institute to examine myocardial biopsies for insights into novel therapeutic approaches for this disease.
Maker.
I have previously developed and donated to the wider community the first CMR fractal analysis tool for left ventricular trabecular quantification which I also tested and validated in the mouse as a means to study cardiac morphogenesis (working with Tim Mohun and Robert Wilson at the NIMR).
I built and tested the first CMR phantom for T1 mapping in collaboration with Senior Physicist Dr Peter Gatehouse at the Brompton Hospital Laboratory. This has now received regulatory clearance from the FDA and CE-mark and is commercially available to support T1 mapping quality assurance in multicenter CMR studies.
I am now fabricating the first SMART-ECGi vest–a cost-effective and re-usable CMR-safe 256 lead high-resolution ECGi vest that will enable deep electromechanical phenotyping of the human heart at scale. This project is a collaboration with ENSAIT (École Nationale Supérieure des Arts et Industries Textiles).
Teaching Summary
For 8 years I voluntarily managed and curated the REDCapSECURE infrastructure for Professor Moon's research group, providing a scalable pan-UK solution for multicenter CMR studies. By 2018 this platform hosted >2150 records for multiple researchers around the UK. In this time I also managed the group's research SFTP DICOM exchange portal and periodically organised educational seminars to train users.
I have been mentoring UCL Cardiovascular Science MSc Student since 2014 the majority of whom graduated with distinction and one was awarded the 2016 SCMR regional scholarship. I have been mentoring students on the UCL iBSc programme since 2017. I tutored on MRCP PACES examination courses from 2007 till 2018, and have regularly lectured MBBS 2nd and 3rd year UCL medical students as part of the cardiometabolic curriculum.
Team:
1. Primary Supervisor of UCL PhD Fellow – Mashael AlFarih conducting a multi-center CMR-driven deep phenotyping study of lamin DCM.
2. Primary Supervisor of Royal Free Hospital trainee and BHF-funded UCL PhD Fellow – Dr Matt Webber, working with the Barcelona Supercomputing Centre to develop electromechanical simulations of the adult human heart using CMR/ECGi data from the MyoFit46 NSHD cardiac sub-study.
3. Secondary Supervisor of BHF-funded UCL PhD Fellow – Dr Rebecca Hughes investigating the CMR and omics phenotype of apical hypertrophic cardiomyopathy.
4. Primary Academic Supervisor of Royal Free Hospital trainee – Dr Debbie Falconer prototyping the first re-usable ECGi jacket.
5. Primary Academic Supervisor of UCL medical student – Cristian Topriceanu using life-course epidemiological approaches to study the association of frailty with later life heart size and function.
6. Primary Academic Supervisor of UCL iBSc student – Eamon Dhall conducting the first EWAS examining the life-course exposures associated with cardiac diastolic dysfunction in older age.
Appointments
| 01-JAN-2019 | Senior Clinical Lecturer | MRC Unit for Lifelong Health and Ageing | UCL, United Kingdom |
| 01-JAN-2019 | Consultant Cardiologist | Inherited Heart Muscle Conditions | Royal Free London, United Kingdom |
| 01-APR-2016 – 20-SEP-2018 | NIHR Rare Diseases Translational Research Fellow (CL IAT) | Institute of Cardiovascular Science | University College London, United Kingdom |
| 01-JAN-2016 – 01-SEP-2018 | ST6 Cardiology Subspecialty: Imaging | Cardiomyopathy | HF | Barts Heart Center | London, United Kingdom |
| 01-APR-2014 – 01-JAN-2016 | NIHR Academic Clinical Fellow Cardiology Registrar | North East London Deanery | Barts Heart Center, United Kingdom |
