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Dr Giuseppe Ercoli
First floor
5, University Street
Dr Giuseppe Ercoli profile picture
  • Research Associate
  • Respiratory Medicine
  • Div of Medicine
  • Faculty of Medical Sciences
I am a microbiologist, working over the years on different fields such as animal models, immunology and molecular biology. My PhD (2010-2013) was based at Novartis Vaccine and Diagnostics in Siena (Italy). I worked on reverse vaccinology approaches for the design and development of vaccines against bacterial pathogens. In particular, I set-up a bactericidal assay to screen vaccine candidates against Haemophilus influenzae and engineered bacterial strains for overproduction and release of Outer Membrane Vesicles (OMV) to be used as vaccine platform. I also studied antigen surface exposure during my PhD, describing the effects of peptidoglycan binding proteins in the export and folding of surface exposed virulence factors. In 2014, I moved to the University of Leicester where I discovered for the first time that Streptococcus pneumoniae has an intracellular replication stage within splenic macrophages. 
Research Summary

I am working at University College of London (UCL) since 2017 studying different aspects of the immunity against pneumococcus. We are currently using a combined approach using a protein array screening and biological conjugation to develop a new conjugate vaccine to prevent pneumococcal infections.

I worked for over ten years on various aspects of microbiology, but my main research interest has always been to understand how bacteria can cause diseases and how we could find a way to prevent them. I studied different bacterial species residing in human nasopharyngeal tract, each one with peculiar characteristics, but all capable to cause infections. Development of vaccines against bacterial pathogens can be considered as my main goal as a researcher and in the different projects that I carried out, I approached most of the different aspects of this research topic: from antigen selection and screening to the study of host immunity, from the characterization of bacterial virulence mechanisms to development of models of protection.

Teaching Summary
I give lectures for the the Microbial Pathogenesis, Principles of Inflammation and Drug Discovery in respiratory medicine modules
10-FEB-2017 Research Associate UCL Respiratory UCL, United Kingdom
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