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Miss GEORGIE LINES profile picture
  • Student
  • UCL Queen Square Institute of Neurology
  • Faculty of Brain Sciences

Georgie Lines completed her bachelor's degree (1st Class Honours) in Biomedical Science (with a year in industry) at Kings College London in 2016. Her year in industry was spent at The Drug Control Centre (KCL), where she analysed biological samples for the presence of prohibited substances. During this year Georgie worked to GLP standards and was involved in screening samples from the 2014 Commonwealth games. Following the completion of her degree, Georgie worked as a Research Assistant at the ARUK UCL Drug Discovery Institute from 2016-2018. As aa member of the screening and pharmacology team at the UCL DDI, Georgie was involved in a range of projects including:
Huntington’s Disease Project: This project is based on the mis-splicing of the Huntington gene RNA transcript, which produces a toxic exon 1 fragment thought to contribute to neurodegeneration in HD. Here Georgie miniaturized and validated a high throughput phenotypic screen to test a library of 250,000 unique compounds.
Alzheimer’s Disease Project (AD): This project is based on modulating the WNT signalling pathway in AD. Georgie developed a cell-based assay to detect small molecule inhibitors of a newly described protein that negatively regulates the WNT signalling pathway, which may be involved in synapse loss in AD.
Georgie is currently completing her PhD at UCL Queens Square Institute of Neurology under the supervision of Prof Selina Wray. Her project is focused on investigating tau proteostasis in development and disease using iPSC-neurons with MAPT mutations linked to FTD. Georgie is a BBRSE CASE student and has spent 4 weeks at AstraZeneca (Cambridge) for her industry placement. In addition to this Georgie has been accepted onto the UCL-Yale student exchange program. Here she will spend 3 months Studying at Yale under the supervision of Prof Mark Hochstrasser.

Research Summary
iPSC-neurons present a unique opportunity to investigate the link between proteostasis and protein aggregation in disease in a physiologically relevant, patient model. Based on transcriptomics, iPSC-neurons are thought to largely resemble foetal neurons, many of the features associated with the development of tau pathology, such as high levels of phosphorylation, are also present in foetal neurons (Patani, et al., 2012). iPSC-neurons with MAPT mutations do not develop tau aggregates (Arber, et al ,. 2017), and this raises the question of why foetal neurons appear to be resistant to the development of tau pathology?. We hypothesis this is due to high activity levels of the proteostasis network during early development. In this project I will investigate the proteostasis capabilities of iPSC-neurons through neuronal development, determine whether mutations in MAPT lead to impaired proteostasis in iPSC-neurons and assess whether manipulation of proteostasis can induce tau pathology.
Teaching Summary
Georgie is very interested in teaching at a university level and would like to gain experience in lecturing at an undergraduate or postgraduate level. During her time at the UCL ARUK DDI, Georgie assisted in supervising a successful Master’s student. Following this, Georgie became a Scientific Advisor for Bioscience Horizons. Scientific Advisors are advanced students or researchers with extensive experience in reviewing and writing scientific literature. At the Journal, each peer reviewer is assigned a Scientific Advisor. Scientific Advisors dedicate around 8hrs/month to guide the Student Peer Reviewers during the peer review process. In addition, Georgie was accepted as an instructor at the ‘Introduction to Neuroscience’ workshop run by Bordeaux School of Neuroscience. Unfortunately, COVID-19 travel restrictions prevented Georgie from attending in 2021, but she plans to re-apply for this opportunity in 2022. During her PhD Georgie has trained numerous students in the culture of iPSCs and the differentiation of iPSCs into neurons.

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