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Dr Gary Parkinson
Rm 438
UCL School of Pharmacy
29/39 Brunswick Square
London
London
WC1N 1AX
Appointment
- Senior Lecturer
- Pharma & Bio Chemistry
- UCL School of Pharmacy
- Faculty of Life Sciences
Biography
Dr Gary Parkinson graduated in Geology from the University of London in 1984. He was then awarded an MSc in crystallography from Birkbeck College, University of London in1988. He graduated from Pittsburgh University (USA) in 1995 with a PhD in crystallography and subsequently joined Rutgers University as a postdoctoral researcher working with Prof. Helen Berman in the investigation of DNA and protein/DNA complexes. He then returned to the UK and joined Prof S. Neidle's group in 1999 moving to The School of Pharmacy in 2002 as a Senior Research Fellow and assistant director of the Biomolecular Structure Group. Dr. Gary Parkinson was appointed as a lecturer in Structural Biology and Chemistry. He now lectures in many aspects of the MPharm degree programme and provides specialist teaching in crystallography.
Research Themes
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Trained as a crystallographer I have sought to build and develop the X-ray resources at UCL School of Pharmacy for both research and teaching. I aim to foster collaborations that should led to new developments in structural biology at the SOP and advance drug delivery platforms.I use crystallographic techniques to investigate and elucidate, at high resolution, the topology and general surface structural features of G-quadruplex DNA and RNA in order to define the modes of interaction of small molecule ligands. To use this information to design and develop new anticancer agents that specifically target quadruplex forming DNA and RNA motifs. The elucidation of both protein and nucleic acid structural components of human telomeres, with a view to finding new molecular targets and discover novel anti-cancer therapeutic agents. The management of a baculovirus expression facility for the production of proteins for structural work. The development of molecular and structural biology resources at The School of Pharmacy and to advance structure based drug design, research and teaching.
