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Prof Sibylle Mittnacht
72 Huntly Street
The UCL Cancer Institute
Paul O'Gorman Building, 72 Huntley Street
Prof Sibylle Mittnacht profile picture
  • Professor of Cell and Molecular Oncology
  • Research Department of Cancer Bio
  • Cancer Institute
  • Faculty of Medical Sciences
Research Themes
Research Summary
We are trying to understand the molecular machinery required for normal  cells to enter the cell division cycle and the mechanisms that leads  such normal cells to cease division activity transiently and terminally. Our work also includes investigating why cancer cells have lost such control and we are seeking to exploit such understanding for the therapy of  cancer.

A unifying and elementary characteristic of cancer is the loss of cell division control. Because of such loos of control cancer cells enter division independent of external cues and remain proliferation active under conditions where normal cells are unable, or cease, to divide. Loss of division control is critically important for the ability of cancers to expand at their primary site AND for the ability of cancer metastasis to establish following spreading of individual cancer cells to remote tissues.
Our research uses a combination of molecular, cell and biochemical technologies, including cell-based high contend screens using chemicals and RNA interference-mediated gene- knock- down, molecular engineering, proteomics and enzyme activity assays. We also study how the cell division control functions impacts therapeutic outcome following conventional and targeted cancer therapeutic intervention







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