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Dr Gillian Tomlinson
1.4.07
Cruciform Building
University College London
London
WC1E 6BT
Appointment
  • MRC Clinician Scientist Research Fellow
  • Div of Infection & Immunity
  • Faculty of Medical Sciences
Biography

I hold a medical degree from Edinburgh University and undertook postgraduate training in general medicine in Glasgow and London. I began my specialist training in respiratory medicine in Glasgow, and subsequently undertook an MRC Clinical Research Training Fellowship leading to a PhD in Immunology at University College London (UCL), which focussed on the roles of monocytes and macrophages in respiratory tract inflammation. I then applied my bioinformatics and computational expertise to discriminate TB, sarcoidosis and cancer in lymph node samples from patients under investigation for mediastinal lymphadenopathy, within my NIHR Academic Clinical Lecturer post. After completing my specialist respiratory training in London, I worked as a consultant respiratory physician in Glasgow, before returning to UCL with an MRC Clinician Scientist Fellowship, which funds my current research programme.

Research Groups
Research Themes
Research Summary

The focus of my lab is to improve understanding of the molecular determinants of both protective and pathogenic immune responses in tuberculosis, which will inform development of novel treatments and vaccines and new ways to stratify risk of active disease.

Differences in the immune response to tuberculosis make a major contribution to clinical outcome, and evidence suggests that the best responses require inflammation to kill the bacteria, balanced by regulation to avoid pathology, but the molecular mechanisms that control this are unclear. We integrate a cutting-edge human experimental tuberculosis challenge model with studies using zebrafish to identify and validate host factors that calibrate a favourable immune response in tuberculosis. The zebrafish Mycobacterium marinum infection model provides a natural host-pathogen interaction with granulomatous inflammation that is an excellent model of human tuberculosis. Moreover, zebrafish larvae are optically transparent allowing us to visualise bacterial growth and cellular responses to infection.

Appointments
01-MAR-2016 Medical Research Council Clinician Scientist Infection and Immunity University College London, United Kingdom
13-APR-2015 – 29-FEB-2016 Consultant in Respiratory and General Medicine   Glasgow Royal Infirmary, United Kingdom
03-OCT-2012 – 10-APR-2015 NIHR Academic Clinical Lecturer Medicine University College London, United Kingdom
03-AUG-2011 – 02-OCT-2012 SpR Respiratory and General Medicine   West of Scotland Deanery, United Kingdom
10-SEP-2007 – 02-AUG-2011 MRC Clinical Research Training Fellow   University College London, United Kingdom
04-AUG-2004 – 03-AUG-2007 SpR Respiratory and General Medicine   West of Scotland Deanery, United Kingdom
04-FEB-2004 – 03-AUG-2004 Experienced SHO Respiratory Medicine   Royal Brompton Hospital, United Kingdom
07-AUG-2003 – 03-FEB-2004 Experienced SHO Respiratory Medicine   Hairmyres Hospital, United Kingdom
07-AUG-2002 – 06-AUG-2003 Experienced SHO Respiratory Medicine   Glasgow Royal Infirmary, United Kingdom
03-AUG-2000 – 06-AUG-2002 SHO Medicine   Glasgow Royal Infirmary, United Kingdom
02-FEB-2000 – 01-AUG-2000 PRHO Surgery   West Cumberland Hospital, United Kingdom
03-AUG-1999 – 01-FEB-2000 PRHO Medicine   St John's Hospital, Livingston, United Kingdom
Academic Background
2012 PhD Doctor of Philosophy – Immunology University College London
2002 MRCP Member of the Royal College of Physicians Royal College of Physicians
1999 MB.ChB Bachelor of Medicine, Bachelor of Surgery – Medicine University of Edinburgh
1996 BSc Hons Bachelor of Science (Honours) – Pathology University of Edinburgh
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