Research in my group spans many aspects of primary immunodeficiencies including genetic diagnosis, molecular and cellular pathogenesis, haematopoietic stem cell transplantation and development of gene therapy. Current lab projects: 1) Understanding the molecular basis of TACI defects in Common Variable Immunodeficiency using in vitro and in vivo models 2) Development of T cell strategies to improve outcome following stem cell transplantation including genetic modification of T cells using suicide genes and generation of virus specific T cells 3) Development of gene therapy models for X-linked lymphoproliferative disease (XLP) and haemophagocytic lymphohistiocytosis (HLH) 4) Gene therapy for severe combined immunodeficiency (X-linked SCID and ADA SCID) + this includes implementation of clinical trials and development of new safer viral constructs Clinical projects 1) Outcome of stem cell transplantation for ADA deficiency 2) Understanding the systemic nature of ADA deficiency 3) Long term cognitive outcome in patients receiving stem cell transplants