RENIN-ANGIOTENSIN SYSTEMS. Work has focussed on their role in regulating tissue (especially cardiac) growth, inflammatory responses (especially in the lung) and in the regulation of human (especially hypoxic) physical performance. Most recently, work continues in studying their role in metabolic regulation.

HUMAN PHYSICAL PERFORMANCE. In 1998, we reported the first allele associated with such performance and have since reported others. Other work has addressed musculoskeletal remodelling and cardiac growth responses to exercise, as well as rthe mechanisms underpinning tendon injury and stress fractures.

CRITICAL CARE MEDICINE. After genetic (and pharmacological) studies of acute lung injury, we are focussed on the skeletal muscle response to critical illness, impacts of altered feeding regimes, and the use of novel energy substrates in neuroprotection.

HYPOXIC ADAPTATION. Hugh was the research lead for the 2007 Caudwell Xtreme Everest Research Expedition, and work continues.

FRIEDRICH'S ATAXIA. We are working ona  potential therapeutic intervention.

ARTIFICIAL INTELLIGENCE AND BIG DATA ANALYTICS. We are working on largescale datasets with the goal of predicting patient decline.

CLIMATE CHANGE and its health consequences is an additional and key focus.