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Dr Charlotte Manisty
Appointment
  • Clinical Senior Lecturer in CMRI and Heart Failure
  • Clinical Science
  • Institute of Cardiovascular Science
  • Faculty of Pop Health Sciences
Biography

Dr Charlotte Manisty is a Senior Lecturer at UCL and a Consultant Cardiologist at the Barts Heart Centre and University College Hospitals, London. She specializes in cardiac imaging and heart failure, and she set up and leads the cardio-oncology service at Barts Heart Centre which sees an average of 400 new patients per year with cancer related cardiovascular problems.  She trained in cardiac device implantation and leads MRI imaging in devices patients at Barts, a service which was awarded both the BMJ and HSJ awards for diagnostic imaging in 2018. 


Her research interests include improving screening for cardiac problems in cancer patients and developing automated techniques for analysis of cardiac structure and function, to improve early detection of cardiac abnormalities.  She also co-wrote the national recommendations for MRI imaging in patients with implantable cardiac devices, and leads a multi-societal working group to address service provision for this patient group.  She also is currently performing research into optimizing scar localization in patients with ventricular arrhythmias.  

Cardio-oncology

  • Senior Author on study of long-term cardiac effects of anthracycline chemotherapy in breast cancer patients
  • PI of 75 patient study assessing clinical tools for cardiac toxicity screening in cancer patients.
  • Designed custom database cardio-oncology (iWeb) for robust, systematic data collection to enable future study recruitment
  • Lead for SCMR Statement on the Role of CMR in Cardio-oncology
  • British Cardio-Oncology Society Board member, invited Scientific Lead (new role)
  • Invited member of Cancer Research Board at Barts Cancer Institute

 MR Imaging in patients with implantable cardiovascular devices

  • Lead of UK Multi-Societal Working Group on MRI for Device patients
  • PI of UK survey of MRI for cardiac device patients demonstrating 50 fold underprovision
  • Co-authored British Heart Rhythm Society Guidance
  • US physics collaboration to develop novel imaging sequences for improved scar imaging in device patients
  • PI on study of safety and clinical utility of optimised scar imaging techniques
  • PI on 1000 patient multi-centre international safety study of MRI in patients with non-MRI conditional pacemaker leads (completed)
  • Co-PI on study using combined MRI and electrophysiological techniques to predict ventricular tachycardia substrates

 Cardio-Orthopaedics

  • Led cross disciplinary (cardio-orthopaedic), cross institutional (Barts, Royal National Orthopaedic Hospital, UCL, Universities of Sheffield and Cardiff) collaboration to assess for a link between metal on metal hip prostheses and heart failure, linking 4 UK National datasets with > 500,000 subjects, showing no population-level link.

 Endocrine

  • PI for cardiac substudy of joint NIHR-Barts Charity funded multi-centre, randomised study in primary hyperaldosteronism, using MRI to investigate the cardiovascular impact of adrenalectomy

Obesity

  • PI for collaborative study with Kings to assess for the impact of bariatric surgery on myocardial perfusion in obesity
Research Summary

Research interests: My new research group focusses on understanding the impact of systemic diseases on heart failure and the myocardium. I am particularly interested in the effects of cancer treatments on the cardiovascular system – methods for early detection and risk stratification, understanding the pathophysiological mechanisms of toxicity, and finding cardio-protective methods to improve outcomes. I also am leading the UK Working Group to understand the barriers and improve provision of MRI scans to patients with implantable cardiac devices.

Current projects:

  • Cardio-oncology - Optimisation of biomarkers for screening for cardiotoxicity
  • Cardio-oncology - Understanding the mechanistic pathways for ibrutinib-related arrhythmias 
  • MRI for patients with cardiac devices - optimising national provision and image quality
  • Predictors of functional recovery following CABG in patients with impaired ventricular function
  • Automated analysis of myocardial and vascular remodelling with abnormal loading (exercise, AS)

  • Impact of bariatric surgery on myocardial perfusion and remodelling
  • MRI-derived substrate mapping of ventricular arrhythmias
  • Integrating Cardiovascular magnetic resonance into hypertension assessment of Conn's Syndrome

Funding: Secured £847,000 in grants as Principal Applicant or Supervisor from the BHF, UCLH BRC, Bart’s Charity and Industry 2016-18 including three Fellowships, with further grants totalling >£90K submitted as Co-Investigator and >£3 million as Collaborator

Research metrics: H index (google scholar) 28, citations 3298, 83 papers on Pubmed

Team: 2 PhD students, research nurse, 2 engineering post-doctoral fellows

External collaborators: Imperial, Kings, Oxford, QMUL, NIH, UPenn 


Teaching Summary

Local
I supervise two PhD fellows currently (both funded via BHF fellowships), and co-supervise one other. Young Investigator award Artery, Lisbon 2018 and short-listed for Early Career Award at SCMR, Washington 2017
Educational supervisor for 3 cardiology trainees
Train 15 Cardiology trainees and 5-10 international visiting fellows annually in cardiac MRI unit at Barts Heart Centre
4 visiting international fellows in cardio-oncology (Netherlands, Spain x2, Mexico) under my supervision 2017-18
I teach and examine regularly on iBSc, MBBS and MSc courses, and examined 5 PhD students from universities in UK and internationally in 2017-18

National
I am Course Director for the only course worldwide on MRI scanning in Cardiac Devices, with funding I secured from Abbott. We ran 6 courses in 2017-19 and trained 33 centres to enable them to run their own services, with consistently excellent feedback. 

International
I give an average of 15 invited talks per year at international conferences (UK, Europe, US) e.g. Heart Failure Society of North America, Global Cardio-Oncology Society, Society of Cardiac Magnetic Resonance (SCMR), European Society of Cardiology (ESC), British Cardiovascular Society, Heart Rhythm Congress
Member of Steering Committee of Global Cardio-oncology Summit 2017 – responsible for organising and delivering largest worldwide conference to date in this field

Appointments
FEB-2016 Clinical Lead for Cardio-oncology Barts Heart Centre Barts Health NHS Trust, United Kingdom
JUN-2014 Senior Lecturer in Heart Failure and Imaging Clinical Cardiology Institute of Cardiovascular Sciences, United Kingdom
Academic Background
2011   Doctor of Philosophy University of London
2004   Member of the Royal College of Physicians Royal College of Physicians
2001   Bachelor of Medicine & Bachelor of Surgery Imperial College of Science, Technology and Medicine
1998   MA Oxon University of Oxford
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