Dr Charlotte Manisty is a Senior Lecturer at UCL and a Consultant Cardiologist at the Barts Heart Centre and University College Hospitals, London. She specializes in cardiac imaging and heart failure, and she set up and leads the cardio-oncology service at Barts Heart Centre which sees an average of 400 new patients per year with cancer related cardiovascular problems.  She trained in cardiac device implantation and leads MRI imaging in devices patients at Barts, a service which was awarded both the BMJ and HSJ awards for diagnostic imaging in 2018. 

Her research interests include improving screening for cardiac problems in cancer patients and developing automated techniques for analysis of cardiac structure and function, to improve early detection of cardiac abnormalities.  She also co-wrote the national recommendations for MRI imaging in patients with implantable cardiac devices, and leads a multi-societal working group to address service provision for this patient group.  She also is currently performing research into optimizing scar localization in patients with ventricular arrhythmias.  

Cardio-oncology

• Senior Author on study of long-term cardiac effects of anthracycline chemotherapy in breast cancer patients
• PI of 75 patient study assessing clinical tools for cardiac toxicity screening in cancer patients.
• Designed custom database cardio-oncology (iWeb) for robust, systematic data collection to enable future study recruitment
• Lead for SCMR Statement on the Role of CMR in Cardio-oncology
• British Cardio-Oncology Society Board member, invited Scientific Lead (new role)
• Invited member of Cancer Research Board at Barts Cancer Institute

 MR Imaging in patients with implantable cardiovascular devices

• Lead of UK Multi-Societal Working Group on MRI for Device patients
• PI of UK survey of MRI for cardiac device patients demonstrating 50 fold underprovision
• Co-authored British Heart Rhythm Society Guidance
• US physics collaboration to develop novel imaging sequences for improved scar imaging in device patients
• PI on study of safety and clinical utility of optimised scar imaging techniques
• PI on 1000 patient multi-centre international safety study of MRI in patients with non-MRI conditional pacemaker leads (completed)
• Co-PI on study using combined MRI and electrophysiological techniques to predict ventricular tachycardia substrates

 Cardio-Orthopaedics

• Led cross disciplinary (cardio-orthopaedic), cross institutional (Barts, Royal National Orthopaedic Hospital, UCL, Universities of Sheffield and Cardiff) collaboration to assess for a link between metal on metal hip prostheses and heart failure, linking 4 UK National datasets with > 500,000 subjects, showing no population-level link.

 Endocrine

• PI for cardiac substudy of joint NIHR-Barts Charity funded multi-centre, randomised study in primary hyperaldosteronism, using MRI to investigate the cardiovascular impact of adrenalectomy

Obesity

• PI for collaborative study with Kings to assess for the impact of bariatric surgery on myocardial perfusion in obesity