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Dr Rob Hynds
Zayed Centre for Research into Rare Disease in Children
UCL Great Ormond Street Institute of Child Health
Dr Rob Hynds profile picture
  • Sir Henry Wellcome Postdoctoral Fellowship
  • Research Department of Oncology
  • Cancer Institute
  • Faculty of Medical Sciences

Rob leads the Epithelial Cell Biology in ENT Research Group within the Stem Cells and Regenerative Medicine Section of the Developmental Biology and Cancer Department at the UCL Great Ormond Street Institute of Child Health. The group's interests are in lung ageing and regeneration, epithelial cell therapy and modelling paediatric cancers to inform therapeutic decisions.

Rob completed his PhD research at UCL Respiratory under the supervision of Dr. Adam Giangreco in 2016, establishing novel 2D and 3D organoid cell culture protocols for the long-term expansion of primary human airway epithelial cells. The main paper describing these results was published in The American Journal of Respiratory and Critical Care Medicine. Rob's expertise in epithelial cell biology led to collaborative work on bioengineering (with Prof. Paolo De Coppi, ICH/GOSH) and on disease modelling, most notably of primary ciliary dyskinesia (with Prof. Chris O’Callaghan, ICH) and SARS-CoV-2 infection (with Dr. Claire Smith, ICH).

During his postdoctoral research, Rob was awarded a Sir Henry Wellcome Fellowship by the Wellcome Trust to develop patient-derived lung cancer models within the lung TRACERx study at The Francis Crick Institute and UCL. This study led to multiple novel insights into lung cancer evolution in the context of modelling, and has generated a resource that is now maintained by the CRUK Lung Cancer Centre of Excellence and has led to multiple collaborative projects including on the roles of mTORC1 and the TSC2/RHEB axis in lung fibrosis (Prof. Rachel Chambers, UCL), lung-to-brain metastasis (Prof. Sheila Singh, McMaster University, Canada), mechanisms of resistance in RAS-driven tumours (Prof. Pablo Rodriguez-Viciana, UCL) and the identification of the AMBRA1-cyclin D pathway as a cell-cycle-regulatory mechanism (Prof. Jiri Bartek, Karolinska Institutet).

Research Groups
Research Themes
Research Summary

02-JAN-2022 GOSH BRC Catalyst Fellow Developmental Biology and Cancer GOS Institute of Child Health, United Kingdom
01-OCT-2019 – 01-JAN-2022 Sir Henry Wellcome Senior Postdoctoral Fellow Cancer Evolution and Genome Instability Laboratory University College London and The Francis Crick Institute, United Kingdom
01-JAN-2018 – 01-OCT-2019 Sir Henry Wellcome Postdoctoral Fellow Cancer Evolution and Genome Instability Laboratory University College London and The Francis Crick Institute, United Kingdom
01-JUL-2016 – 31-DEC-2017 Postdoctoral Research Associate Translational Cancer Therapeutics, UCL Cancer Institute University College London and The Francis Crick Institute, United Kingdom
01-JUL-2012 – 30-JUN-2016 PhD Student UCL Respiratory University College London, United Kingdom
Academic Background
2016   Doctor of Philosophy University College London
2012   Bachelor of Science University of Durham
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