Irwin Nazareth’s research interests include the management of mental health problems in primary care.  This includes the management in primary care of: physical health in people with psychological disorders; the prevention and management of depression, addiction disorders (i.e. tobacco, alcohol and prescribed drugs) and unexplained medical symptoms such as dizziness and sexual dysfunction; the evaluation of existing and new interventions in primary care and the community and the implementation of research finding in clinical practice.  His methodological expertise is in the design and conduct of randomised trials of complex interventions and the analysis of big data (clinical databases) for epidemiological, aetiological and health service research. He has over the years secured funding from the MRC, the Wellcome Trust, Cancer Research UK, The European Commission and the National Institute of Health Research (NIHR) for these programmes of research.  He is currently the Director of the PRIMENT Clinical Trials Unit that has a large portfolio of randomised trials on primary care and mental health. His international research interests include research on primary care and mental health in Europe and  India.