Irwin Nazareth’s research interests include the physical health of people with psychological disorders; the prevention and management of depression and unexplained medical symptoms such as dizziness and sexual dysfunction in primary care; the evaluation of interventions on the implementation of research in clinical practice and those designed to change individuals' health behaviour especially smoking and weight management.  His methodological expertise is in the design and conduct of systematic reviews; randomised trials of complex interventions and the use of large clinical databases such CPRD and THIN for epidemiological, aetiological and health service research.  He has over the years secured funding from the MRC, the Wellcome Trust, Cancer Research UK, The European Commission and the National Institute of Health Research (NIHR) for these programmes of research.  He is currently the Director of the PRIMENT Clinical Trials Unit that has a large portfolio of randomised trials on primary care and mental health. His international research interests include research on primary care and mental health in Europe, India, South Africa and China.