Institutional Research Information Service
UCL Logo
Please report any queries concerning the funding data grouped in the sections named "Externally Awarded" or "Internally Disbursed" (shown on the profile page) to your Research Finance Administrator. Your can find your Research Finance Administrator at https://www.ucl.ac.uk/finance/research/rs-contacts.php by entering your department
Please report any queries concerning the student data shown on the profile page to:

Email: portico-services@ucl.ac.uk

Help Desk: http://www.ucl.ac.uk/ras/portico/helpdesk
 More search options
Prof Ivan Gout
Darwin Building
Gower St
  • Professor of Cancer Biochemistry
  • Structural & Molecular Biology
  • Div of Biosciences
  • Faculty of Life Sciences

I graduated as an MD at Lviv State Medical University (Ukraine) in 1983 with a great passion to become a surgeon in oncology. Thinking that a PhD in experimental oncology would help to realize my dream, I obtained my doctorate at the Institute of Experimental Oncology, National Academy of Sciences of Ukraine in 1987. A fellowship from the International Agency for Research on Cancer (IARC) took me even further from clinical oncology and also from Ukraine. I arrived in London on the first wave of perestroika and began my post-doctoral training in Jim Woodgett's laboratory at the Ludwig Institute for Cancer Research (UCL Branch). Subsequently, I worked in Mike Waterfield's laboratory at the same Institute studying signal transduction via the PI3 kinase pathway. In 1996, I started my own group at the Ludwig Institute for Cancer Research, focusing on the regulation of growth via the S6 kinase pathway. Since 2003, I have been a Professor in the Department of Biochemistry at UCL – now renamed Structural and Molecular Biology, where I have an active research group working on signal transduction and cellular metabolism in health and disease. I have a strong research (113 papers in peer-reviewed journals, H-Index 52) and patent (10 world-wide patents) portfolio and run two drug discovery programs aimed at developing small molecule inhibitors, targeting ribosomal S6 kinase and Aurora A kinase.

Research Groups
Research Themes
Research Summary

The main focus of research in my laboratory is the study of basic mechanisms by which cell growth and metabolism are regulated in normal and cancer cells. There are two major areas of interest in the laboratory: a) regulation of cellular functions via the mTOR/S6K signalling pathway; and b) the role of Coenzyme A and its derivatives in cellular metabolism and gene expression. The development of novel diagnostic and therapeutic approaches for cancer is the ultimate goal of our research, which we pursue through collaboration with academic and industrial partners. We have an ongoing collaboration with Johnson & Johnson on targeting ribosomal S6 kinases for the development of novel anti-cancer drugs. In addition, we collaborate with Xanofi Ltd on utilizing nanofibre/microfibre scaffolds developed by this biotech company for 3D cell culturing and setting up 3D cancer models for academic research and testing the efficacy of new cancer drugs. Our challenge is to establish highly reproducible in vitro cultivation of patient-derived cancer and stromal cells, both from primary samples and associated lymph node and distant metastases in optimized nano/microfiber scaffolds in order to evaluate anti-cancer drug sensitivity for personalized anticancer chemotherapy.

Teaching Summary

I am the Graduate Admission Tutor in the Department of Structural and Molecular Biology, the Lead Tutor in Biotechnology for the MRes in Biosciences and course organizer BIOC2014. I lecture and give tutorials on growth regulation and cell signalling to second and third year students. I also supervise third year students for laboratory projects. I am course organiser for CPD Lecture and Practical course “Lab Techniques in Mammalian Cell Biology” at UCL.

2003 Professor of Cancer Biochemistry Biosciences University College London, United Kingdom
1996 – 2003 Group Leader Growth Regulation Ludwig Institute for Cancer Research, UCL Branch, United Kingdom
1993 – 1996 Senior Research Scientist Cell Signalling Ludwig Institute for Cancer Research, UCL Branch, United Kingdom
1989 – 1993 Postdoctoral Fellow Cell Signalling Ludwig Institute for Cancer Research, United Kingdom
1988 – 1989 IARC Postdoctoral Fellow Cell signalling Ludwig Institute for Cancer Research, United Kingdom
Academic Background
1987 PhD Doctor of Philosophy – Biochemistry National Academy of Science
1983 MD Doctor of Medicine – Medicine Lviv Medical University
Please report any queries concerning the data shown on this page to https://www.ucl.ac.uk/hr/helpdesk/helpdesk_web_form.php
University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

© UCL 1999–2011

Search by