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Prof Jurg Bahler
Room 329 Darwin Building
Institute of Healthy Ageing
UCL Department of Genetics, Evolution & Environment
London
WC1E 6BT
Prof Jurg Bahler profile picture
Appointment
  • Chair in Molecular Systems Biology
  • Genetics, Evolution & Environment
  • Div of Biosciences
  • Faculty of Life Sciences
Biography

Jürg Bähler completed his PhD studies on meiotic chromosome metabolism at the University of Bern (Switzerland) under the supervision of Jürg Kohli. After short stays as a Research Associate in Japan and Switzerland, he worked as a Postdoctoral Fellow with John Pringle at the University of North Carolina (Chapel Hill, USA) and with Paul Nurse at the Imperial Cancer Research Fund (London, UK), studying cellular morphogenesis and cell-cycle regulation. In 2000, Bähler joined the Wellcome Trust Sanger Institute (Hinxton, UK) as a Group Leader, and in 2009 was appointed as a Professor of Systems Biology at University College London.

Research Summary

The characteristics of organisms result largely from the dynamic interplay between DNA or RNA and the regulatory apparatus. The control of gene expression is fundamental to implement the information in the genome and to determine the properties of different organisms. Gene expression is regulated at multiple levels, and cells need to integrate external and internal cues and coordinate different regulatory levels to properly exert biological functions. We study transcriptional and post-transcriptional gene expression programmes during cellular proliferation, quiescence/ageing, and stress response using Schizosaccharomyces pombe as a model system. We apply multiple genetic and high-throughput approaches for systems-level understanding of regulatory networks and complex relationships between genotype, phenotype, and environment, including roles of genome variation and evolution, transcriptome regulation, and non-coding RNAs. 

Recently, we have started to work with the turqouise killifish (Nothobranchius furzeri), a short-lived vertebrate model to study ageing and associated diseases.

Teaching Summary

Undergraduate Courses:

BIOC0004 - Introduction to Microbiology BIOL1004

BIOC0030 - Advanced Molecular Biology of Protein Regulatory Networks

BIOL0025 - Advanced Molecular Biology: Genomics and Evolution


Graduate Courses:

Principles in Biology (BBSRC LIDo DTP)

CoMPLEX ABC



Appointments
01-OCT-2019 Director, Institute of Healthy Ageing GEE UCL, United Kingdom
01-MAY-2009 Professor of Systems Biology GEE UCL, United Kingdom
01-MAR-2000 – 30-APR-2009 Investigator   Wellcome Trust Sanger Institute, United Kingdom
Academic Background
1994   Doctor of Philosophy Universitat Bern
1990   Bachelor of Science Universitat Bern
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