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Prof John Carroll
Department of Cell and Developmental Biology
UCL, Gower St
  • Honorary Professor
  • Div of Biosciences
  • Faculty of Life Sciences
Research Summary
How does an oocyte develop and then make the transition into a viable embryo? This is the basic question that research in our lab is aimed at understanding. To tackle this problem we use techniques in cell and molecular biology combined with live cell imaging to understand the processes that underlie oocyte and embryo development. Moving from the earliest stages to the latest, the specific problems we are working on in the laboratory include: 1. What determes the number of primordial follicles that form in the ovary? 2. The initiation of oocyte growth. 3. The control and role of mitochondrial fission, migration and metabolism during oocyte growth and maturation. 4. Control of the meiotic cell cycle and assymmetric cell division. 5. Role of signalling in cell proliferation and cell death in the preimplantation embryo. 6. Development of optimal culture conditions for oocytes and embryos.
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University College London - Gower Street - London - WC1E 6BT Tel:+44 (0)20 7679 2000

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