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Dr Jennie Chandler
UCL Great Ormond Street Institute of Child Health
30 Guilford St
London
London
WC1N 1EH
Dr Jennie Chandler profile picture
Appointment
  • Research Associate
  • Developmental Biology & Cancer Dept
  • UCL GOS Institute of Child Health
  • Faculty of Pop Health Sciences
Biography

  • BSc (Hons), Biology, University of Exeter, UK (2010-2013)
  • PhD, Molecular Biology, University of the Sunshine Coast, Australia (2013-2017)
  • Research Assistant, University of the Sunshine Coast, Australia (2017-2018)
  • Research Associate, UCL Great Ormond Street Institute of Child Health, UK, 2018-2021
  • BRC Catalyst Fellow, UCL Great Ormond Street Institute of Child Health, UK, 2021- 2022
Research Summary

I am a NIHR BRC Catalyst Fellow working in the Kidney Development and Disease group at UCL Great Ormond Street Institute of Child Health. My research is focused on improving treatment options for childhood renal failure. To achieve this, my aims are to (i) improve the models that we use to study disease, (ii) apply these models to clinically relevant cases to determine the drivers of kidney damage and iii) trial therapies to treat them. 


This work has led me to discover new mechanisms acting in kidney disease, including a newly described mutation in a gene called NOP10. NOP10 is involved in RNA processing and is central to ribosomal biology and telomere maintenance. This work was the first to describe a role for ribosomal RNA processing in glomerular disease. 


I also work on another more commonly implicated gene in childhood kidney disease, called Wilms’ Tumour 1 (WT1). Using kidney organoids and single cell RNA sequencing, I am interested in how genetic mutations in WT1 affect its function and disrupt cell - cell signalling in the kidney glomerulus. Findings from this work will allow us to identify targeted genetic therapies that can be used to restore disrupted pathways in disease. 


Reflecting this, the third theme of my research is to improve how we deliver genetic therapies to the kidney, using cell-targeted lipid nanocomplexes and adeno-associated viral approaches. 

Teaching Summary

Supervision

  1. MRC PhD Secondary Supervisor, VIPAR and VPS33b in kidney disease, GOSICH, 2021- ongoing
  2. LIDo PhD Secondary Supervisor, Nanocomplexes as a novel renal therapy, GOSICH, 2020 - ongoing
  3. PhD Thesis Committee, Indian hedgehog signalling in kidney disease, GOSICH, 2019- ongoing


Teaching

  • Programme lead for ICH Skills Exchange Series for PhD and MSc students, GOSICH, 2021- ongoing
  • Research & Teaching Department Representative for DBC, GOSICH, 2021- ongoing
  • Associate Fellow of the Higher Education Academy, UCL, 2019
Appointments
01-NOV-2021 Research Fellow Developmental Biology and Cancer UCL Great Ormond Street Institute of Child Health, United Kingdom
01-JAN-2018 – 31-OCT-2021 Research Associate Developmental Biology and Cancer UCL Great Ormond Street Institute of Child Health, United Kingdom
Academic Background
2019   ATQ02 - Recognised by the HEA as an Associate Fellow University College London
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