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Prof Jayne Tierney
MRC Clinical Trials Unit at UCL
90 High Holborn
Prof Jayne Tierney profile picture
  • Professor of Evidence Synthesis
  • MRC Clinical Trials Unit at UCL
  • Inst of Clinical Trials &Methodology
  • Faculty of Pop Health Sciences
Jayne co-leads the Meta-analysis Programme of the MRC Clinical Trials Unit at UCL (MRC CTU). For more than 25 years, she has been responsible for designing and conducting systematic reviews and meta-analysis to rigorously re-evaluate the effectiveness of therapies firstly at the MRC Cancer Trials Office and subsequently MRC CTU. Jayne has been involved in the Cochrane Collaboration since its beginnings, providing peer review for Cochrane Review Groups, contributing to the Cochrane Handbook, and presenting workshops at annual meetings and colloquia. She is one of the co-convenors of the IPD Meta-analysis Methods Group.
Research Themes
Research Summary

Jayne and her team have published international, collaborative, individual participant data (IPD) meta-analyses in bladder, cervix, lung, oesophageal, and soft-tissue cancer, and she has advised on projects in e.g. in pregnancy and wound care. These projects have influenced practice guidelines and the treatment of patients worldwide. In addition, she has been involved in systematic reviews of aggregate data in stroke, HIV, and fertility medicine, as well as in cancer. Currently, she is focused on the evaluation of the effects of therapies for prostate cancer, TB and COVID-19.

Also, Jayne is committed to improving how systematic reviews and meta-analyses are conducted and analysed to ensure their quality and utility for improving patients outcomes. Her current methodological interests include developing prospective, collaborative approaches to aggregate data meta-analyses to improve their timeliness and reliability, and the appropriately analysis treatment-covariate interactions in meta-analysis are to ensure treatments are given to those who benefits most. She also provides advice and training on systematic review and meta-analysis methods, particularly in relation to IPD.


Teaching Summary
Jayne teaches about systematic review and meta-analysis methods for UCL undergraduate and post-graduate courses, and through external seminars, webinars, workshops and conference presentations. 
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