Jayne and her team have published international, collaborative, individual participant data (IPD) meta-analyses in bladder, cervix, lung, oesophageal, and soft-tissue cancer, and she has advised on projects in e.g. in pregnancy and wound care. These projects have influenced practice guidelines and the treatment of patients worldwide. In addition, she has been involved in systematic reviews of aggregate data in stroke, HIV, and fertility medicine, as well as in cancer. Currently, she is focused on the evaluation of the effects of therapies for prostate cancer, TB and COVID-19.

Also, Jayne is committed to improving how systematic reviews and meta-analyses are conducted and analysed to ensure their quality and utility for improving patients outcomes. Her current methodological interests include developing prospective, collaborative approaches to aggregate data meta-analyses to improve their timeliness and reliability, and the appropriately analysis treatment-covariate interactions in meta-analysis are to ensure treatments are given to those who benefits most. She also provides advice and training on systematic review and meta-analysis methods, particularly in relation to IPD.