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Mr Jeffrey Mah
Office 521
UCL Great Ormond Street Institute of Child Health
30 Guilford Street
Mr Jeffrey Mah profile picture
  • Post Graduate Teaching Assistant
  • Dept of Chemistry
  • Faculty of Maths & Physical Sciences
Jeffrey works in Institute of Child Health and Department of Chemistry of University College London for research in drug discovery for skin diseases. His current research interest include drug discovery from natural products, chemical synthesis to modify and improve efficacy and selectivity of natural products, and developing therapeutic intervention for skin disease.
Research Groups
Research Summary
My research currently focuses on development of specific serine protease inhibitors based on Sunflower Trypsin Inhibitor 1 scaffold – application for skin conditions with aberrant serine protease activities. Jeffrey is developing and synthesising a novel inhibitor predominantly only for kallikrein 5 (KLK5), a protease involving in the pathogenesis of atopic dermatitis (AD, eczema) and Netherton syndrome (NS) ; and ii) examine the potential of SFTI inhibitory effect for the type II transmembrane serine protease (TMPRSS2), a serine protease involved in the priming of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spike proteins (S-protein), to see whether we can use SFTI as a scaffold to develop an inhibitor for TMPRSS2, which it could provide a new way to prevent/reduce the risk of virus infection for patients with chronic inflammatory skin condition such as AD and NS.

  Post Graduate PhD Student Infection, Immunity & Inflammation Dept UCL GOS Institute of Child Health, United Kingdom
Academic Background
  BSc Hons Bachelor of Science in Pharmaceutical Studies University College London (UCL)
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